Betaxolol Impurity 7 CAS 91878-54-5
| CAS No. | 91878-54-5 |
| Molecular Formula | C18H29NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Betaxolol Impurity 7.
As a process- or degradation-related impurity, Betaxolol Impurity 7 (CAS 91878-54-5, C18H29NO3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Betaxolol Impurity 7 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 343.89 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H29NO3 HCl |
| Molecular Weight | 343.89 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Betaxolol Standards
- Betaxolol Impurity 6 (CAS 116209-55-3)
- Betaxolol-d5 (CAS 1189957-99-0)
- Betaxolol Impurity 9 (CAS 131564-69-7)
- Betaxolol EP Impurity E (CAS 1329613-85-5)
- Betaxolol EP Impurity E (Hydrochloride Salt) (CAS 2724726-61-6)
- Betaxolol EP Impurity A Hydrochloride (CAS 464877-45-0)
- Betaxolol EP Impurity D (CAS 63659-16-5)
- Betaxolol EP Impurity C (CAS 63659-17-6)
Recommended Standards
- Pirfenidone Impurity 35 (CAS 2412-49-9)
- Butylphthalide Impurity 43 (CAS CATO-C4X-181343)
- Phenoxymethylpenicillin Impurity 22 (CAS CATO-C4X-212622)
- 1-(Pyrazin-2-yl)-1H-imidazole-4-carbohydrazide (CAS 1355227-02-9)
- Methyl 2-(3-{3-[(pyrrolidin-1-yl)carbonyl]phenyl}phenyl)acetate (CAS 1820614-94-5)
- 4-(4-((Dibutylamino)methyl)phenyl)-5-hydroxyisoquinolin-1(2H)-one (CAS 651029-12-8)
- Pentoxifylline Impurity 25 (CAS 57987-84-5)
- 3-Amino-1-(pyridin-3-yl)propan-1-ol (CAS 41403-92-3)
- 2-Hydrazino-6-propoxypyrazine (CAS 1343709-50-1)
- Liraglutide-d8 Tritrifluoroacetate (CAS CATO-C4X-199223)
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