Amorolfine Impurity 5 CAS 922734-43-8
| CAS No. | 922734-43-8 |
| Molecular Formula | C16H25NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Amorolfine Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Amorolfine Impurity 5 (CAS 922734-43-8) is a certified pharmaceutical impurity reference standard with the molecular formula C16H25NOHCl and a molecular weight of 283.84 g/mol.
The molecular framework of Amorolfine Impurity 5 (C16H25NOHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H25NO HCl |
| Molecular Weight | 283.84 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Amorolfine Standards
- Amorolfine EP Impurity F (CAS 106614-66-8)
- Amorolfine Hydrochloride - Impurity G (CAS 1260498-34-7)
- Amorolfine EP Impurity G HCl (CAS 1260498-35-8)
- Amorolfine EP Impurity B (CAS 142347-84-0)
- Amorolfine Impurity 87 (CAS 1688675-10-6)
- Amorolfine Impurity 89 (CAS 1689944-83-9)
- Amorolfine Impurity 62 (CAS 1800302-57-1)
- trans-Amorolfine (CAS 2134097-34-8)
Recommended Standards
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- Ethyl 2-(3-phenoxypropanamido)thiazole-4-carboxylate (CAS 329269-86-5)
- 9-Chloro-8-hydroxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one (CAS 2226905-29-7)
- 2-Amino-5-bromothiophene-3-carboxylic acid (CAS 1784352-12-0)
- 6-ethoxy-3H-1,3-benzothiazol-2-one (CAS 72680-01-4)
- Tert-butyl 4-(((5-chlorofuran-2-yl)methyl)amino)piperidine-1-carboxylate (CAS 1355894-35-7)
- 5-Methyl-3,4'-bipyridine (CAS 362478-91-9)
- Semaglutide Impurity 1(OtBu-Ste-D-γGlu(OtBu)-AEEA-AEEA-OH) (CAS CATO-C4X-22261)
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