Amorolfine EP Impurity G HCl CAS 1260498-35-8
| CAS No. | 1260498-35-8 |
| Molecular Formula | 2*C21H33NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Amorolfine EP Impurity G HCl (CAS 1260498-35-8) is a certified pharmaceutical impurity reference standard with the molecular formula C21H33NO2HCl and a molecular weight of 367.96 g/mol.
The molecular framework of Amorolfine EP Impurity G HCl (C21H33NO2HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Amorolfine EP Impurity G HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C21H33NO2 2*HCl |
| Molecular Weight | 367.96 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Amorolfine Standards
- Amorolfine EP Impurity F (CAS 106614-66-8)
- Amorolfine Hydrochloride - Impurity G (CAS 1260498-34-7)
- Amorolfine EP Impurity B (CAS 142347-84-0)
- Amorolfine Impurity 87 (CAS 1688675-10-6)
- Amorolfine Impurity 89 (CAS 1689944-83-9)
- Amorolfine Impurity 62 (CAS 1800302-57-1)
- trans-Amorolfine (CAS 2134097-34-8)
- Amorolfine lmpurity 25 (CAS 2497333-07-8)
Recommended Standards
- Capivasertib Impurity 40 (CAS CATO-C4X-331240)
- Dalbavancin Impurity 58 (CAS CATO-C4X-160258)
- Zonisamide Impurity 1 (CAS CATO-C4X-17851)
- 4-Chloro-6-ethoxy-2-phenylquinoline (CAS 860197-69-9)
- (2-Bromo-3-(2-methoxyethoxy)phenyl)methanamine (CAS 2025971-96-2)
- N-Ethyl-1-methyl-3-phenoxy-N-propyl-1H-pyrazole-4-carboxamide (CAS 477697-75-9)
- 2-(Aminomethyl)-6-(difluoromethyl)-4-hydroxypyridine-3-carboxylic acid (CAS 1805531-81-0)
- Lurasidone (CAS 367514-87-2)
- Neopentyl Stearate (CAS 102253-41-8)
- Des-His(1)-Semaglutide (CAS CATO-C4X-2226216)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com