1-[4-(difluoromethoxy)phenyl]-2,5-dimethyl-1h-pyrrole-3-carbaldehyde CAS 923749-90-0
| CAS No. | 923749-90-0 |
| Molecular Formula | C14H13F2NO2 |
| Molecular Weight | 265.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-[4-(difluoromethoxy)phenyl]-2,5-dimethyl-1h-pyrrole-3-carbaldehyde is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-[4-(difluoromethoxy)phenyl]-2,5-dimethyl-1h-pyrrole-3-carbaldehyde (CAS 923749-90-0) is a high-purity analytical reference standard with the molecular formula C14H13F2NO2 and a molecular weight of 265.26 g/mol.
The molecular framework of 1-[4-(difluoromethoxy)phenyl]-2,5-dimethyl-1h-pyrrole-3-carbaldehyde (C14H13F2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-[4-(difluoromethoxy)phenyl]-2,5-dimethyl-1h-pyrrole-3-carbaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H13F2NO2 |
| Molecular Weight | 265.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related difluoromethoxy Standards
- 6-(Difluoromethoxy)-4'-methoxy-[1,1'-biphenyl]-3-amine (CAS 851814-10-3)
- 2-(2-(Difluoromethoxy)-5-hydroxybenzoyl)pyridine (CAS 1261592-28-2)
- 2-(5-(Difluoromethoxy)-2-hydroxybenzoyl)pyridine (CAS 1261677-67-1)
- 2-(2-(Difluoromethoxy)-4-hydroxybenzoyl)pyridine (CAS 1261728-86-2)
- 2-(4-(Difluoromethoxy)-3-hydroxybenzoyl)pyridine (CAS 1261769-48-5)
- 2-(2-(Difluoromethoxy)-3-hydroxybenzoyl)pyridine (CAS 1261787-16-9)
- 2-(3-(Difluoromethoxy)-5-hydroxybenzoyl)pyridine (CAS 1261787-33-0)
- (3-(Difluoromethoxy)-5-hydroxyphenyl)(pyridin-4-yl)methanone (CAS 1261787-51-2)
Recommended Standards
- 1-(5-(Trifluoromethyl)-1,3,4-thiadiazol-2-yl)piperidine-4-carbaldehyde (CAS 958443-35-1)
- 1-Oxo-2-phenyl-1,2-dihydroisoquinoline-4-carboxylic acid (CAS 78364-18-8)
- 1-(4-Phenoxyphenyl)-1H-pyrrole-2,5-dione (CAS 69422-82-8)
- 2-(((3,4-Difluorophenyl)amino)methyl)-6-methoxyphenol (CAS 864420-98-4)
- 2-Cyano-N-(2,5-dichlorophenyl)-3-(pyridin-3-yl)propanamide (CAS 505065-31-6)
- 7-Bromo-3-cyclopropylbenzo[d]isoxazole (CAS 1428881-45-1)
- 5-(4,5-Dimethoxy-2-nitrophenyl)-1,3,4-oxadiazol-2(3H)-one (CAS 1216654-38-4)
- 4-(1-Hydroxy-2-methylpropan-2-yl)benzoic acid (CAS 75492-21-6)
- 5-bromopyrrolo[2,1-f][1,2,4]triazin-2-amine (CAS 1368241-32-0)
- 3-[(6-Chlorothiazolo[5,4-β]pyridin-2-yl)methoxy]-2,6-difluorobenzamide (CAS 951120-33-5)
- 5-Phenyl-7-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxamidoxime (CAS 1965308-70-6)
- Di(1H-pyrazol-4-yl)methane (CAS 13753-57-6)
- 2-Amino-5-(4-fluorophenyl)thiophene-3-carboxamide (CAS 61019-14-5)
- Cholecystokinin Octapeptide (sulfated) (H-2060.0005) (CAS 25679-23-6)
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