Methyl 4-(difluoromethoxy)-1h-indole-2-carboxylate CAS 926219-45-6
| CAS No. | 926219-45-6 |
| Molecular Formula | C11H9F2NO3 |
| Molecular Weight | 241.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 4-(difluoromethoxy)-1h-indole-2-carboxylate.
CATO supplies Methyl 4-(difluoromethoxy)-1h-indole-2-carboxylate (CAS 926219-45-6), a certified reference material (molecular formula C11H9F2NO3, MW 241.19 g/mol) for analytical method development and quality control.
The molecular framework of Methyl 4-(difluoromethoxy)-1h-indole-2-carboxylate (C11H9F2NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Methyl 4-(difluoromethoxy)-1h-indole-2-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H9F2NO3 |
| Molecular Weight | 241.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- Methyl 2-((3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)thio)acetate (CAS 461431-84-5)
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- Ethyl 4-methyl-2-methylenepentanoate (CAS 87438-94-6)
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- 3-Methyl-4-(3-methylphenoxy)-[1,2]oxazolo[5,4-d]pyrimidine (CAS 672925-15-4)
- 5-((2-(2,5-Dimethylphenoxy)ethyl)thio)-1,3,4-thiadiazol-2-amine (CAS 923156-04-1)
- Sanggenol L (CAS 329319-20-2)
- 4-(2-Chloro-6-fluorophenyl)thiazol-2-amine (CAS 287197-07-3)
- tert-Butyl ((4-bromopyridin-3-yl)methyl)carbamate (CAS 1060812-91-0)
- Methyl 3-nitro-4-sulfamoylbenzoate (CAS 162010-79-9)
- N-(3-Ethyl-5-oxo-1H-1,2,4-triazol-4(5H)-yl)propionamide (CAS 223795-10-6)
- Tau Peptide (306-336) (Repeat 3 Domain) trifluoroacetate salt (CAS 330456-26-3)
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