Cabozantinib Impurity 40 CAS 1275738-77-6
| CAS No. | 1275738-77-6 |
| Molecular Formula | C11H9F2NO3 |
| Molecular Weight | 241.19 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Cabozantinib Impurity 40 (C11H9F2NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 241.19 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Cabozantinib Impurity 40 (CAS 1275738-77-6), a pharmacopoeial impurity reference standard (molecular formula C11H9F2NO3, MW 241.19 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H9F2NO3 |
| Molecular Weight | 241.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Cabozantinib Standards
- Cabozantinib Impurity N2 (CAS 113136-79-1)
- Cabozantinib Impurity 4 (CAS CATO-C4X-20184)
- Cabozantinib 4-Fluorocarbamoyl Methyl Ester Impurity (CAS 1345847-71-3)
- Cabozantinib Impurity 21 (CAS 849217-49-8)
- Cabozantinib Impurity 19 (CAS CATO-C4X-201819)
- Cabozantinib Impurity 52 (CAS CATO-C4X-201852)
- Cabozantinib Impurity 43 (CAS CATO-C4X-201843)
- Cabozantinib Impurity 28 (CAS 326-04-5)
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- 1-(pyrrolidin-3-yl)-1H-1,2,3-triazole dihydrochloride 1955557-41-1 Z2465619836 (CAS 1955557-41-1)
- 4-(5-Isopropyl-2-methylphenoxy)aniline (CAS 946775-48-0)
- 7-Amino-6-phenyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione (CAS 62437-11-0)
- 2-Bromo-5-(difluoromethyl)-6-(hydroxymethyl)nicotinonitrile (CAS 1804463-18-0)
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