2-Fluoro-5-[2-(trifluoromethoxy)phenyl]benzoic acid CAS 926255-81-4
| CAS No. | 926255-81-4 |
| Molecular Formula | C14H8F4O3 |
| Molecular Weight | 300.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Fluoro-5-[2-(trifluoromethoxy)phenyl]benzoic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Fluoro-5-[2-(trifluoromethoxy)phenyl]benzoic acid (CAS 926255-81-4) is a high-purity analytical reference standard with the molecular formula C14H8F4O3 and a molecular weight of 300.21 g/mol.
2-Fluoro-5-[2-(trifluoromethoxy)phenyl]benzoic acid (C14H8F4O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Fluoro-5-[2-(trifluoromethoxy)phenyl]benzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H8F4O3 |
| Molecular Weight | 300.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Fluoro Standards
- 2-Fluoro-5-(4-trifluoromethoxyphenyl)benzoic acid (CAS 1178497-48-7)
- 2-Fluoro-4-(4-trifluoromethoxyphenyl)benzoic acid (CAS 1178720-03-0)
- 4-Fluoro-4'-(trifluoromethoxy)biphenyl-2-carboxylic acid (CAS 1183674-44-3)
- 2-Fluoro-4'-(trifluoromethoxy)biphenyl-3-carboxylic acid (CAS 1261449-75-5)
- 4-Fluoro-3'-(trifluoromethoxy)biphenyl-2-carboxylic acid (CAS 1261460-00-7)
- 5-Fluoro-3-(3-trifluoromethoxyphenyl)benzoic acid (CAS 1261460-04-1)
- 3-Fluoro-4-(3-trifluoromethoxyphenyl)benzoic acid (CAS 1261524-83-7)
- 2-Fluoro-3'-(trifluoromethoxy)biphenyl-3-carboxylic acid (CAS 1261558-22-8)
Recommended Standards
- 2-Bromo-5-methyl-spiro[6H-thieno[3,2-c]pyridine-7,1'-cyclopentane]-4-one (CAS 2789682-27-3)
- 3-(3-Fluorophenoxy)-5-(trifluoromethyl)pyridine-2-carboxamide (CAS 338758-78-4)
- 2-(3-Bromophenyl)-1-morpholinoethanethione (CAS 26580-58-5)
- 3-(4-Fluorophenoxy)-5-(trifluoromethyl)pyridine-2-carboxamide (CAS 338758-83-1)
- 1-Phenyl-3-(4-propoxyphenyl)-1H-pyrazole-4-carbaldehyde (CAS 431920-75-1)
- 5-(Chloromethyl)-3-phenyl-1,2,4-oxadiazole hydrochloride (CAS 1171499-00-5)
- tert-Butyl 1-phenyl-6,7-dihydro-1H-pyrazolo[4,3-b]pyridine-4(5H)-carboxylate (CAS 1421312-09-5)
- Tert-butyl (S)-2-amino-4,4-dimethylpentanoate (CAS 195310-75-9)
- 1-(2-Chloroallyl)-2-(methylsulfonyl)-1H-imidazole (CAS 1384694-69-2)
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- 3-Bromo-4-phenoxybenzonitrile (CAS 183111-00-4)
- (1R,3S,5R)-2-Boc-2-azabicyclo[3.1.0]hexane-3-carboxylic Acid (CAS 197142-34-0)
- 141801-03-8 IL-1 Receptor Peptide (human) (CAS 141801-03-8)
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