Methylprednisolone EP Impurity G CAS 93269-35-3
| CAS No. | 93269-35-3 |
| Molecular Formula | C22H28O4 |
| Molecular Weight | 356.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Methylprednisolone EP Impurity G (C22H28O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Methylprednisolone EP Impurity G (CAS 93269-35-3), a pharmacopoeial impurity reference standard (molecular formula C22H28O4, MW 356.46 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H28O4 |
| Molecular Weight | 356.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >80% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
Related Methylprednisolone Standards
- Methylprednisolone EP Impurity D (CAS 1338549-02-2)
- Methylprednisolone EP Impurity D(E-Isomer) (CAS CATO-C4X-19194)
- Methylprednisolone Impurity 79 (CAS CATO-C4X-191979)
- Methylprednisolone impurity 6 (CAS CATO-C4X-191986)
- Methylprednisolone Acetate EP Impurity I (CAS 6870-94-6)
- Methylprednisolone Impurity 57 (CAS 1048031-80-6)
- Methylprednisolone Impurity 81 (CAS 82332-00-1)
- Methylprednisolone EP Impurity E (CAS 229019-44-7)
Recommended Standards
- Thiamine nitrate EP Impurity H (CAS 89285-03-0)
- Thiamine Impurity 59 (CAS CATO-C4X-187359)
- Butylphthalide Impurity 81 (CAS 2408731-72-4)
- Fluorometholone Impurity B (CAS 83873-16-9)
- Tofacitinib Impurity 8 (CAS CATO-C4X-10798)
- Venetoclax Impurity 50 (CAS CATO-C4X-249550)
- Ulipristal Impurity 27 (CAS 1655514-79-6)
- 2,4-Diiodo-5-methylpyridine (CAS 1196884-09-9)
- 4-(trideuteriomethoxy)tetrahydropyran-4-carboxylic acid (CAS 2306263-70-5)
- {3-[(4-methoxybenzoyloxy)methyl]-4-oxo-3,4-dihydro-2H-1-benzothiopyran-3-yl}methyl 4-methoxybenzoate (CAS 339028-86-3)
- (1R,2S)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol (CAS 2792-51-0)
- {[2-(4-Methoxy-phenyl)-ethylcarbamoyl]-methylsulfanyl}-acetic acid (CAS 380469-11-4)
- 1-((4-Bromophenyl)sulfonyl)-4-chloro-5-nitro-1H-pyrrolo[2,3-b]pyridine (CAS 1429309-33-0)
- Anorexigenic Peptide (CAS 69275-10-1)
Why CATO?
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