(E)-5-(2-(7-Chloro-1H-indol-4-yl)vinyl)-N-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)thiazol-2-amine CAS 936845-71-5
| CAS No. | 936845-71-5 |
| Molecular Formula | C22H22ClN7S |
| Molecular Weight | 451.97 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies (E)-5-(2-(7-Chloro-1H-indol-4-yl)vinyl)-N-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)thiazol-2-amine (CAS 936845-71-5), a certified reference material (molecular formula C22H22ClN7S, MW 451.97 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution, (E)-5-(2-(7-Chloro-1H-indol-4-yl)vinyl)-N-(2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)thiazol-2-amine is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 451.97 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H22ClN7S |
| Molecular Weight | 451.97 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related E Standards
- N-(3-Chloro-4-fluorophenyl)-2-((3-ethyl-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 578001-69-1)
- 1-((2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methyl-N-(tetrahydrofuran-3-yl)piperidin-4-amine (CAS 1147423-11-7)
- N-(4-Chloro-2-methylphenyl)-2-((5-((4-methoxybenzyl)thio)-1,3,4-thiadiazol-2-yl)thio)acetamide (CAS 477313-77-2)
- N-(5-chloro-2-methoxyphenyl)-2-((4-phenyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 332376-29-1)
- (R)-5-Chloro-N-(3-methoxy-1-((3-methyl-4-(3-oxomorpholino)phenyl)amino)-1-oxopropan-2-yl)thiophene-2-carboxamide (CAS 811811-33-3)
- (2Z)-2-[3-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}methyl)-1H-1,2,4-triazol-5-yl]-3-(4-methoxyphenyl)prop-2-enenitrile (CAS 321430-71-1)
- 4-((4-((2-Chloro-4-nitrophenoxy)methyl)benzyl)oxy)benzene-1-sulfonyl fluoride (CAS 31185-39-4)
- (3-(3-((2-Chloro-6-fluorobenzyl)oxy)phenyl)-1H-pyrazol-1-yl)(4-nitrophenyl)methanone (CAS 477712-56-4)
Recommended Standards
- Fmoc-Cys(Bzl)-Cl (CAS 103321-55-7)
- 4-(4-(4-Chlorophenyl)-2-(propan-2-ylidenehydrazono)thiazol-3(2H)-yl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (CAS 402946-48-9)
- Haloperidol EP Impurity E (CAS 1391054-69-5)
- Haloperidol EP Impurity F (CAS 1391052-67-7)
- 4-Fluoro-3-methyl-o-phenylenediamine (CAS 485832-95-9)
- 4-Amino-6-(difluoromethyl)-5-(hydroxymethyl)pyridin-2-ol (CAS 1804679-36-4)
- RMC6236 Intermediate 4 (CAS CATO-CIM-103892)
- Mycophenolic acid (CAS 24280-93-1)
- N-((5-(N-(3-Chlorophenyl)sulfamoyl)-2-methylphenyl)carbamothioyl)-4-fluorobenzamide (CAS 379696-86-3)
- 2-Phenoxy-N-(pyridin-3-yl)acetamide (CAS 25288-46-4)
- 1-Ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazide (CAS 74693-62-2)
- 2-Amino-2-(4-fluoro-phenyl)-propionic acid (CAS 312-44-7)
- Dapoxetine Impurity 101 (CAS CATO-C4X-1439101)
- Semaglutide Impurity 162 (x TFA Salt) (CAS CATO-C4X-2226162)
Why CATO?
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