Haloperidol EP Impurity F CAS 1391052-67-7
| CAS No. | 1391052-67-7 |
| Molecular Formula | C27H27ClFNO2 |
| Molecular Weight | 451.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Haloperidol EP Impurity F (CAS 1391052-67-7), a pharmacopoeial impurity reference standard (molecular formula C27H27ClFNO2, MW 451.96 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Haloperidol EP Impurity F (C27H27ClFNO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 451.96 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H27ClFNO2 |
| Molecular Weight | 451.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Haloperidol Standards
- Haloperidol EP Impurity E (CAS 1391054-69-5)
- Haloperidol Impurity 11 (CAS 75478-79-4)
- Haloperidol Decanoate EP Impurity A (CAS 1797824-64-6)
- Haloperidol EP Impurity C (CAS 1391052-87-1)
- Haloperidol Decanoate EP Impurity H (CAS 1134807-34-3)
- trans-Haloperidol N-Oxide (CAS 150214-93-0)
- Haloperidol impurity 25 (CAS 150214-94-1)
- Haloperidol Impurity 9 (CAS 148406-51-3)
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