Donepezil Impurity 61 CAS 937362-16-8
| CAS No. | 937362-16-8 |
| Molecular Formula | C31H36NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Donepezil Impurity 61 (CAS 937362-16-8, C31H36NO3Cl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Donepezil Impurity 61 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 506.08 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C31H36NO3 Cl |
| Molecular Weight | 506.08 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Donepezil Standards
- Donepezil Impurity 15 (CAS 1023500-88-0)
- Donepezil Impurity 44 (CAS 1026443-48-0)
- Donepezil Impurity 46 (CAS 1034439-43-4)
- Donepezil-d5 (CAS 1128086-25-8)
- Donepezil Impurity 55 (CAS 1189443-74-0 (free base))
- Donepezil Related Compound A HCl (CAS 120011-69-0)
- Donepezil Hydrochloride (CAS 120011-70-3)
- Donepezil Impurity 25 (CAS 120012-04-6)
Recommended Standards
- Folic Acid Impurity 35 (CAS 33157-07-2)
- Apixaban Impurity 82 (CAS 2614-10-0)
- Oxcarbazepine Impurity 8 (CAS 59690-99-2)
- N-[(4-Methylphenyl)methyl]-2-{4-oxo-7-phenyl-3H,4H-thieno[3,2-d]pyrimidin-3-yl}acetamide (CAS 1105234-85-2)
- tert-Butyl 3-(aminomethyl)-3-methylazepane-1-carboxylate (CAS 1823794-69-9)
- 4-Methyl-3-(2,3,3-trimethylbutyl)-1h-pyrazol-5-amine (CAS 1347088-79-2)
- Vonoprazan Impurity 224 (CAS CATO-C4X-1020224)
- (s)-2-Fluoro-6-(1-hydroxyethyl)phenol (CAS 1932309-57-3)
- 2,4-Dichloropyrimidine-5-sulfonyl Chloride (CAS 23920-08-3)
- [5-31]-Semaglutide (CAS CATO-C4X-2226263)
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