1-(2-Chloroethyl)-3-(4-(trifluoromethoxy)phenyl)urea CAS 937601-75-7
| CAS No. | 937601-75-7 |
| Molecular Formula | C10H10ClF3N2O2 |
| Molecular Weight | 282.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-(2-Chloroethyl)-3-(4-(trifluoromethoxy)phenyl)urea is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-(2-Chloroethyl)-3-(4-(trifluoromethoxy)phenyl)urea (CAS 937601-75-7) is a high-purity analytical reference standard with the molecular formula C10H10ClF3N2O2 and a molecular weight of 282.65 g/mol.
1-(2-Chloroethyl)-3-(4-(trifluoromethoxy)phenyl)urea (C10H10ClF3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10ClF3N2O2 |
| Molecular Weight | 282.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloroethyl Standards
- 1-Chloroethyl [4-(trifluoromethyl)phenyl]methyl carbonate (CAS 1965305-08-1)
- 2-(1-Chloroethyl)-5,6,7,8-tetrahydro-7-methyl[1]benzothieno[2,3-d]pyrimidin-4(1H)-one (CAS 733030-56-3)
- 2-Chloroethyl (2,2-dichlorovinyl) ethyl phosphate (CAS 3568-51-2)
- 2-(2-Chloroethyl)-7-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine (CAS 878217-85-7)
- Methyl 4-(4-(2-chloroethyl)piperidin-1-yl)benzoate (CAS 936130-71-1)
- Methyl 2-[2-(2-chloroethyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl]acetate (CAS 866134-77-2)
- 2-(1-Chloroethyl)-5-(furan-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one (CAS 877041-23-1)
- 3-(3-(2-Chloroethyl)ureido)benzene-1-sulfonyl fluoride (CAS 13908-51-5)
Recommended Standards
- [5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl cyclopropanecarboxylate (CAS 282523-60-8)
- 3-(3-Chloro-4-fluorophenoxy)-5-nitroaniline (CAS 861440-00-8)
- 3-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)benzonitrile (CAS 1823184-10-6)
- 4-((2-Chloro-5-fluoropyrimidin-4-yl)oxy)-3-methoxybenzaldehyde (CAS 525570-78-9)
- 2-(4-Chloro-2-fluoropyridin-3-yl)acetic acid (CAS 1805954-94-2)
- CAS 55066-41-6 (CAS 55066-41-6)
- 2-Bromo-4-chloro-5-(trifluoromethoxy)aniline (CAS 1805213-02-8)
- 3-(2-(1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-ylidene)hydrazinyl)quinoxalin-2(1H)-one (CAS 338412-85-4)
- 2-(2-Pyridinylamino)-benzenethiol (CAS 158438-81-4)
- 3-amino-1-chloro-3-methylpentan-2-one hydrochloride (CAS 201932-98-1)
- (6-Methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methanamine (CAS 1355995-86-6)
- Dodec-2-en-1-yl acetate (CAS 38363-23-4)
- 6-(4-(Hydroxymethyl)phenyl)pyridin-3-ol (CAS 1255634-42-4)
- Palmitoyl Tripeptide-1 HCl (CAS 2757690-14-3)
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