3-Chloro-2-(3-methoxyphenoxy)aniline CAS 937604-67-6
| CAS No. | 937604-67-6 |
| Molecular Formula | C13H12ClNO2 |
| Molecular Weight | 249.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Chloro-2-(3-methoxyphenoxy)aniline.
3-Chloro-2-(3-methoxyphenoxy)aniline (CAS 937604-67-6) is a high-purity analytical reference standard with the molecular formula C13H12ClNO2 and a molecular weight of 249.69 g/mol.
3-Chloro-2-(3-methoxyphenoxy)aniline (C13H12ClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Chloro-2-(3-methoxyphenoxy)aniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H12ClNO2 |
| Molecular Weight | 249.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 3-Chloro-2-(2-methoxyphenoxy)aniline (CAS 946714-63-2)
- 3-Chloro-2-(4-methoxyphenoxy)aniline (CAS 937604-65-4)
- 3-[(4-Chlorophenyl)methoxy]-2-methyl-1,4-dihydropyridin-4-one (CAS 303151-78-2)
- 3-Chloro-4-(2-methoxyphenoxy)phenylamine (CAS 87294-24-4)
- Tert-butyl (4-bromo-2-chlorobenzyl)carbamate (CAS 864266-10-4)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-methyl-1H-pyrazol-5-amine (CAS 172600-30-5)
- 2,10-di-tert-butyl 13-bromo-2,4,10-triazatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,12,14-hexaene-2,10-dicarboxylate (CAS 1934303-18-0)
- Indolo[3,2,1-ij]quinolino[4,5-bc][1,5]naphthyridine (CAS 85412-78-8)
- N-Benzylidene-2,6-dichloropyrimidin-4-amine (CAS 920975-25-3)
- N-(5-Isopropyl-1,3,4-thiadiazol-2-yl)-1-naphthamide (CAS 392243-25-3)
- 4-Ethylpiperazine-2-carboxylic acid dihydrochloride (CAS 1709876-15-2)
- 4-(Difluoromethyl)-2-iodo-5-methylpyridine-3-sulfonyl chloride (CAS 1805608-27-8)
- 2-(3-(((2-(tert-Butoxy)-2-oxoethyl)amino)methyl)pyrrolidin-1-yl)acetic acid (CAS 1353966-74-1)
- Semaglutide Impurity 147 (CAS CATO-C4X-2226147)
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