2-[6-(4-fluorophenyl)-3-methyl-4-(trifluoromethyl)-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 937605-88-4
| CAS No. | 937605-88-4 |
| Molecular Formula | C16H11F4N3O2 |
| Molecular Weight | 353.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-[6-(4-fluorophenyl)-3-methyl-4-(trifluoromethyl)-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid.
2-[6-(4-fluorophenyl)-3-methyl-4-(trifluoromethyl)-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid (CAS 937605-88-4), molecular formula C16H11F4N3O2 and molecular weight 353.27 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 2-[6-(4-fluorophenyl)-3-methyl-4-(trifluoromethyl)-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 353.27 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-[6-(4-fluorophenyl)-3-methyl-4-(trifluoromethyl)-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H11F4N3O2 |
| Molecular Weight | 353.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related fluorophenyl Standards
- Ethyl 3-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-6-carboxylate (CAS 685109-47-1)
- Ethyl 5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 333761-24-3)
- 5-(4-(2-Fluorophenyl)piperazin-1-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile (CAS 324009-07-6)
- 5-(4-(4-Fluorophenyl)piperazin-1-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile (CAS 324009-05-4)
- Methyl 1-(2-fluorophenyl)-6-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1011397-81-1)
- 2-{1-[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]ethyl}-2,3-dihydro-1H-isoindole-1,3-dione (CAS 1795518-55-6)
- Benzyl (2-(5-(4-fluorophenyl)-1H-imidazol-2-yl)propan-2-yl)carbamate (CAS 1261118-02-8)
- N-(3-Fluorophenyl)-5-methyl-11-oxo-5H,5aH,6H,7H,8H,9H,11H-pyrido[2,1-b]quinazoline-3-carboxamide (CAS 1574583-66-6)
Recommended Standards
- [(2R,3S,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-2-(hydroxymethyl)tetrahydrofuran-3-yl] dihydrogen phosphate (CAS 6220-62-8)
- 4-Chloro-1-(2-chloro-2-phenylethyl)-6-(ethylthio)-1H-pyrazolo[3,4-d]pyrimidine (CAS 679805-52-8)
- 5-Fluoro-2-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-4-methyl-6-(methylsulfonyl)pyrimidine (CAS 1823182-68-8)
- tert-butyl 3-[5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]azetidine-1-carboxylate (CAS 2304634-91-9)
- 1-[(4-Bromo-3,5-dimethyl-1H-pyrazol-1-yl)methyl]-3,5-dimethyl-1H-pyrazol-4-amine hydrochloride (CAS 1049752-43-3)
- Ethyl 2-bromo-4-cyano-6-(trifluoromethyl)benzoate (CAS 1805937-87-4)
- PF 184 (CAS 1187460-81-6)
- 3-Iodo-1-(phenylsulfonyl)-5-(phenylthio)-1H-pyrrolo[2,3-b]pyridine (CAS 923583-57-7)
- 1-(2-Bromo-1-(3-methoxypropoxy)ethyl)-3-fluorobenzene (CAS 1250652-36-8)
- (6-chloropyridine - 3-methyl) amino ethane (CAS 120739-77-7)
- Ethyl 2-amino-4-methyl-5-(morpholine-4-carbonyl)thiophene-3-carboxylate (CAS 314046-67-8)
- Ethyl (2E)-2-cyano-3-{[4-(naphthalen-2-yl)-1,3-thiazol-2-yl]amino}prop-2-enoate (CAS 478258-32-1)
- 5-bromo-4-chlorofuro[2,3-d]pyrimidine (CAS 1256789-37-3)
- Tirzepatide Impurity 11 TFA salt (CAS CATO-C4X-324011)
Why CATO?
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