2-[3-cyclopropyl-4-(difluoromethyl)-6-methyl-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 937607-22-2
| CAS No. | 937607-22-2 |
| Molecular Formula | C13H13F2N3O2 |
| Molecular Weight | 281.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 281.26 g/mol gives 2-[3-cyclopropyl-4-(difluoromethyl)-6-methyl-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-[3-cyclopropyl-4-(difluoromethyl)-6-methyl-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid (CAS 937607-22-2) is a high-purity analytical reference standard with the molecular formula C13H13F2N3O2 and a molecular weight of 281.26 g/mol.
Structurally, 2-[3-cyclopropyl-4-(difluoromethyl)-6-methyl-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid (C13H13F2N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 281.26 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-[3-cyclopropyl-4-(difluoromethyl)-6-methyl-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C13H13F2N3O2 |
| Molecular Weight | 281.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related cyclopropyl Standards
- Methyl 6-cyclopropyl-1-(2,2-difluoroethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1018125-73-9)
- 6-Cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1018142-22-7)
- 2-(6-Cyclopropyl-4-(difluoromethyl)-3-methyl-1h-pyrazolo[3,4-b]pyridin-1-yl)acetic acid (CAS 937607-09-5)
- Ethyl 5-cyclopropyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 512825-94-4)
- 3-Cyclopropyl-6-(pyridin-3-yl)-[1,2]oxazolo[5,4-b]pyridine-4-carboxylic acid (CAS 954574-15-3)
- 3-Cyclopropyl-6-(pyridin-4-yl)isoxazolo[5,4-b]pyridine-4-carboxylic acid (CAS 954259-72-4)
- 6-Cyclopropyl-2-(pyrrolidin-1-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile (CAS 478049-65-9)
- 3-(1-Cyclopropyl-6-fluoro-1h-benzo[d]imidazol-2-yl)-2-methylaniline (CAS 1354952-41-2)
Recommended Standards
- 2,3-Dimethyl-6-nitroanthracene-9,10-dione (CAS 61415-71-2)
- 2-Benzyl-1,3-dioxoisoindoline-5-carboxylic acid (CAS 67822-75-7)
- 2,3-Dimethyl-1-nitroanthracene-9,10-dione (CAS 61415-76-7)
- 3-([1,1'-Biphenyl]-4-yloxy)-4-hydroxy-1H-pyrrole-2,5-dione (CAS 77529-44-3)
- tert-Butyl(2-cyanoethyl)carbamate (CAS 53588-95-7)
- 4-((tert-Butyldimethylsilyl)oxy)butan-1-ol (CAS 87184-99-4)
- (R)-tert-Butyl 2-(4-(4-chlorophenyl)thiazol-2-yl)piperidine-1-carboxylate (CAS 1089729-73-6)
- 3-(2-Ethylphenyl)-3-hydroxypropanoic acid (CAS 1248111-75-2)
- (e)-3-(4-Bromo-2-fluorophenyl)prop-2-en-1-ol (CAS 149946-67-8)
- 4-(4-Fluorobenzoyl)-1-(2-fluorobenzyl)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one (CAS 317833-43-5)
- 6-Chloro-2-methyl-1H-indole (CAS 6127-17-9)
- Methyl 4-chloro-3-(fluorosulfonyl)benzoate (CAS 1955499-69-0)
- (R)-5-amino-1-fluoro-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-ol (CAS 2388489-85-6)
- Glucagon (19-29) (human, rat, porcine) (CAS 64790-15-4)
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