6-Cyclopropyl-2-(pyrrolidin-1-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile CAS 478049-65-9
| CAS No. | 478049-65-9 |
| Molecular Formula | C14H14F3N3 |
| Molecular Weight | 281.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 6-Cyclopropyl-2-(pyrrolidin-1-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile (C14H14F3N3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
6-Cyclopropyl-2-(pyrrolidin-1-yl)-4-(trifluoromethyl)pyridine-3-carbonitrile (CAS 478049-65-9) is a high-purity analytical reference standard with the molecular formula C14H14F3N3 and a molecular weight of 281.28 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H14F3N3 |
| Molecular Weight | 281.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Cyclopropyl Standards
- 3-Cyclopropyl-6-(pyridin-3-yl)-[1,2]oxazolo[5,4-b]pyridine-4-carboxylic acid (CAS 954574-15-3)
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- Methyl 6-cyclopropyl-1-(2,2-difluoroethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1018125-73-9)
- 6-Cyclopropyl-1-(2,2-difluoroethyl)-3-methyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1018142-22-7)
- 2-(6-Cyclopropyl-4-(difluoromethyl)-3-methyl-1h-pyrazolo[3,4-b]pyridin-1-yl)acetic acid (CAS 937607-09-5)
- 2-[3-cyclopropyl-4-(difluoromethyl)-6-methyl-1h-pyrazolo[3,4-b]pyridin-1-yl]acetic acid (CAS 937607-22-2)
- Ethyl 5-cyclopropyl-7-(difluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 512825-94-4)
- 3-(1-Cyclopropyl-6-fluoro-1h-benzo[d]imidazol-2-yl)-2-methylaniline (CAS 1354952-41-2)
Recommended Standards
- 6-(1-Methyl-1H-pyrazol-4-yl)-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline (CAS 2137044-44-9)
- 8-Fluoro-3-methyl-2-phenylquinoline-4-carboxylic acid (CAS 861438-77-9)
- 6- Acetamido- 4- hydroxy- 2- naphthalenesulfonic Acid (CAS 6361-41-7)
- diethyl 2-[(2-fluoroanilino)methylene]malonate (CAS 63010-68-4)
- 3-(3-Hydroxyquinoxalin-2-yl)acrylic acid (CAS 91135-67-0)
- 1,4-DIchloro-2-fluoro-3-(propan-2-yloxy)benzene (CAS 1395038-43-3)
- N-(4-Fluorophenyl)-2-[(3,4,4-trifluorobut-3-en-1-yl)sulfanyl]pyridine-3-carboxamide (CAS 339106-84-2)
- N-(5-Cyclopropoxy-6-fluoropyridin-2-yl)methanesulfonamide (CAS 1243396-50-0)
- 3,5-Dimethoxy-4-methylbenzaldehyde (CAS 1011-27-4)
- 3-(5,6-Dibromo-1,3-dioxooctahydro-2H-4,7-methanoisoindol-2-yl)benzoic acid (CAS 101758-77-4)
- Dalilesen impurity 47 (CAS CATO-C4X-301047)
- Ethyl 1-isopropyl-1H-pyrazole-3-carboxylate (CAS 1007514-99-9)
- Methyl 3-(piperidin-2-yl)propanoate (CAS 57440-27-4)
- Fragment-[7-31]-Liraglutide (CAS CATO-C4X-199239)
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