Lorazepam EP Impurity E CAS 93955-15-8
| CAS No. | 93955-15-8 |
| Molecular Formula | C15H8Cl2N2O |
| Molecular Weight | 303.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lorazepam EP Impurity E.
Lorazepam EP Impurity E (CAS 93955-15-8) is a certified pharmaceutical impurity reference standard with the molecular formula C15H8Cl2N2O and a molecular weight of 303.14 g/mol.
Based on its molecular formula C15H8Cl2N2O, Lorazepam EP Impurity E contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 303.14 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H8Cl2N2O |
| Molecular Weight | 303.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lorazepam Standards
Recommended Standards
- 91742-21-1 SC-73770 Sodium(I) Bis(trifluoromethanesulfonyl)imide (CAS 91742-21-1)
- Ozenoxacin Impurity 32 (CAS CATO-C4X-279632)
- Oxadiazon-hydroxy Solution (CAS 39807-19-7)
- Ethacrynic Acid (CAS 58-54-8)
- Naproxen EP Impurity O (CAS 2471-70-7)
- Mivacurium chloride Impurity 30 (CAS CATO-C4X-137530)
- Nilotinib Impurity N1 Nitrate salt (CAS 1025716-99-7)
- 201740-95-6 (~13~C_6_)Phenylmethanol DTXSID70584347 (CAS 201740-95-6)
- (1R,5S)-9-methyl-3,9-diazabicyclo[3.3.1]Nonan-7-amine (CAS 166171-16-0)
- 1,1'-Bipyrazole (CAS 90499-57-3)
- 2-(((1-(Benzylsulfonyl)piperidin-4-yl)methyl)thio)-4-methylthiazole (CAS 1428357-46-3)
- 7-bromo-4-(methylsulfanyl)pyrrolo[2,1-f][1,2,4]triazine (CAS 1370007-54-7)
- 2-(4-Chlorophenyl)-4-oxo-1,4-dihydroquinoline-6-carboxylic acid (CAS 90034-16-5)
- Polyphemusin II-Derived Peptide (CAS 229030-20-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com