Naproxen EP Impurity O CAS 2471-70-7
| CAS No. | 2471-70-7 |
| Molecular Formula | C12H10O3 |
| Molecular Weight | 202.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 202.21 g/mol gives Naproxen EP Impurity O distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Naproxen EP Impurity O (CAS 2471-70-7) is a certified pharmaceutical impurity reference standard with the molecular formula C12H10O3 and a molecular weight of 202.21 g/mol.
The molecular framework of Naproxen EP Impurity O (C12H10O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Naproxen EP Impurity O meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H10O3 |
| Molecular Weight | 202.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Naproxen Standards
- Naproxen EP Impurity K (CAS 77301-42-9)
- Naproxen EP Impurity L (CAS 3900-45-6)
- Naproxen Impurity 29 (CAS 17056-94-9)
- Naproxen Impurity 32 (CAS 5672-94-6)
- Naproxen Impurity 40 (CAS 36815-04-0)
- Naproxen Impurity 52 (CAS CATO-C4X-170852)
- Naproxen Impurity 16 (CAS 34352-92-6)
- Naproxen Impurity 6 (CAS 174172-95-3)
Recommended Standards
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