2-(4-Fluorophenyl)pyrazine CAS 939975-25-4
| CAS No. | 939975-25-4 |
| Molecular Formula | C10H7FN2 |
| Molecular Weight | 174.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(4-Fluorophenyl)pyrazine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(4-Fluorophenyl)pyrazine (CAS 939975-25-4) is a high-purity analytical reference standard with the molecular formula C10H7FN2 and a molecular weight of 174.17 g/mol.
The molecular framework of 2-(4-Fluorophenyl)pyrazine (C10H7FN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(4-Fluorophenyl)pyrazine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7FN2 |
| Molecular Weight | 174.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluorophenyl Standards
- 2-(2-Fluorophenyl)pyrimidine (CAS 1214349-37-7)
- 2-(3-Fluorophenyl)pyrazine (CAS 1286755-19-8)
- 2-(3-Fluorophenyl)pyrimidine (CAS 68049-16-1)
- 4-(4-Fluorophenyl)pyrimidine (CAS 68049-19-4)
- 5-(3-Fluorophenyl)pyrimidine (CAS 68049-20-7)
- 5-(4-Fluorophenyl)pyrimidine (CAS 68049-21-8)
- (3-Fluorophenyl)methanesulfinic acid (CAS 1892392-25-4)
- 2-Fluorophenyl Methyl Sulfone (CAS 654-47-7)
Recommended Standards
- 2-(4-Fluoro-1H-indol-3-yl)acetonitrile (CAS 89434-04-8)
- 2-(5-Fluoro-1h-indol-3-yl)acetonitrile (CAS 73139-85-2)
- 2-(7-Fluoro-1H-indol-3-yl)acetonitrile (CAS 959236-14-7)
- 2-(2-Fluorobenzyl)malononitrile (CAS 338965-16-5)
- Ethyl 4-methyl-5-oxo-2,5-dihydroisoxazole-3-carboxylate (CAS 84280-59-1)
- Isothiocyanatophenyl sulfone (CAS 4430-49-3)
- Crocetin dimethyl ester (CAS 5892-54-6)
- 2-Amino-3-bromo-5-(trifluoromethyl)pyridine (CAS 79456-30-7)
- 4-Amino-5-benzoyl-2-((4-fluorobenzyl)thio)thiophene-3-carbonitrile (CAS 478081-57-1)
- 6,7-Dihydro-5H-cyclopenta[c]pyridine-1,7-diamine dihydrochloride (CAS 2096419-54-2)
- 4,5,6,7-Tetrabromo-1H-benzotriazole (CAS 17374-26-4)
- pyrimidine-4,5,6-triamine sulfate hydrate (CAS 6640-23-9)
- Barium 2-amino-3-(phosphonooxy)propanoate(1:x) (CAS 58823-92-0)
- Semaglutide impurity 195 (CAS CATO-C4X-2226195)
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