Buspirone EP Impurity A DiHCl CAS 94021-22-4
| CAS No. | 94021-22-4 |
| Molecular Formula | C8H12N4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Buspirone EP Impurity A DiHCl (C8H12N4HCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 200.67 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Buspirone EP Impurity A DiHCl (CAS 94021-22-4) is a certified pharmaceutical impurity reference standard with the molecular formula C8H12N4HCl and a molecular weight of 200.67 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Buspirone EP Impurity A DiHCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12N4 2*HCl |
| Molecular Weight | 200.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1983 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Buspirone Standards
- Buspirone impurity 01 (CAS 105496-33-1)
- Buspirone EP Impurity K (CAS 1075-89-4)
- Buspirone EP Impurity A-d8 (Buspirone USP Related Compound A-d8) (CAS 1309283-31-5)
- Buspirone Impurity 9 (CAS 13220-24-1)
- Buspirone Impurity 21 (CAS 137583-05-2)
- Buspirone Impurity 24 (CAS 1800242-04-9)
- Buspirone Impurity 20 (CAS 1821194-01-7)
- Buspirone Impurity 23 (CAS 20261-27-2)
Recommended Standards
- Ethambutol Hydrochloride EP Impurity A (CAS 96-20-8)
- CAS 2452301-13-0 (CAS 2452301-13-0)
- Dabigatran Impurity 72 (CAS 637238-96-0)
- 4-(3,5-Dimethoxyphenyl)butanenitrile (CAS 1057672-62-4)
- 2-(3-Hydroxyoxetan-3-yl)-2-methylpropanoic acid (CAS 2110640-99-6)
- 1-Benzyl-N-(3,5-dichlorophenyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxamide (CAS 338412-50-3)
- ((2S,4R)-2-Methyltetrahydro-2H-thiopyran-4-yl)sulfamic acid (CAS 787517-18-4)
- 3-(4-acetyl-5-methyl-2-furyl)propanoic acid (CAS 858247-32-2)
- 1-(2-Fluoro-4-(methylsulfonyl)phenyl)piperidine-4-carboxamide (CAS 914637-63-1)
- Nonapeptide-1 (CAS 158563-45-2)
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