2-Chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile CAS 943117-82-6

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile.

2-Chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile (CAS 943117-82-6), molecular formula C13H8ClFN2 and molecular weight 246.67 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 2-Chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile (C13H8ClFN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

CATO manufactures 2-Chloro-6-(4-fluorophenyl)-4-methylnicotinonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.

Physical & Chemical Properties

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