4-(Trifluoromethyl)-2-pyrimidineethanamine CAS 944898-59-3
| CAS No. | 944898-59-3 |
| Molecular Formula | C7H8F3N3 |
| Molecular Weight | 191.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(Trifluoromethyl)-2-pyrimidineethanamine (CAS 944898-59-3), molecular formula C7H8F3N3 and molecular weight 191.15 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Trifluoromethyl)-2-pyrimidineethanamine (C7H8F3N3) is characterized by a nitrile group, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H8F3N3 |
| Molecular Weight | 191.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Trifluoromethyl Standards
- 2-[6-(Trifluoromethyl)pyridin-3-yl]ethan-1-ol (CAS 1000528-63-1)
- 1-[1-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]ethan-1-one (CAS 1068468-94-9)
- 1-Methyl-3-(trifluoromethyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole (CAS 1083224-56-9)
- (6-Methyl-2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridin-3-yl)methanol (CAS 113265-44-4)
- (R)-1-(2-(trifluoromethyl)pyrimidin-5-yl)ethan-1-amine (CAS 1150263-75-4)
- 3-Oxo-3-(1-(trifluoromethyl)cyclobutyl)propanenitrile (CAS 1188909-23-0)
- 2-(trifluoromethyl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrazine (CAS 1196154-97-8)
- alpha-(Trifluoromethyl)-6-methylpyridine-3-methanol (CAS 1226507-25-0)
Recommended Standards
- 4-(Aminomethyl)-2-(trifluoromethyl)phenol (CAS 916303-81-6)
- 4,5,6,7-Tetrahydro-3-(trifluoromethyl)-1H-pyrazolo[4,3-c]pyridine (CAS 743419-80-9)
- 4-(2,2-Difluoroethoxy)-3-fluoroaniline (CAS 937598-60-2)
- 4-Methoxy-2-(trifluoromethyl)aniline (CAS 53903-49-4)
- 3-BROMO-2-IODOCYCLOPENT-2-EN-1-OL (CAS 892145-43-6)
- H-Ile-His-OH (CAS 97284-12-3)
- 1-(4-Chlorophenyl)-2-(2-chloropyrimidin-4-yl)ethanone (CAS 646527-94-8)
- 1-Amino-3-cyclopentyl-2-methylpropan-2-ol (CAS 1491923-55-7)
- (3-Chloro-4-fluorophenyl)(2-chlorobenzyl)sulfane (CAS 1443332-14-6)
- (4-Methyl-4-(pyridin-3-yl)pyrrolidin-3-yl)methanol (CAS 1823671-99-3)
- 3-Noradamantanecarbonyl chloride 3-Noradamantanoyl chloride 67064-09-9 Hexahydro-2,5-methanopentalene-3a(1H)-carbonyl chloride (CAS 67064-09-9)
- 7,7-Difluoro-1-phenyl-3-azabicyclo[4.1.0]Heptane hydrochloride (CAS 1955515-73-7)
- 1-Benzyl-3-methylenepyrrolidine (CAS 150543-34-3)
- Fragment-[9-31]-Semaglutide (CAS CATO-C4X-2226181)
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