Sitagliptin Impurity 156 CAS 945261-49-4
| CAS No. | 945261-49-4 |
| Molecular Formula | C16H15F6N5O |
| Molecular Weight | 407.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Sitagliptin Impurity 156 (C16H15F6N5O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Sitagliptin Impurity 156 (CAS 945261-49-4, C16H15F6N5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H15F6N5O |
| Molecular Weight | 407.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Sitagliptin Standards
- Sitagliptin EP Impurity A (CAS 823817-55-6)
- Sitagliptin Impurity 116 (CAS 945261-50-7)
- Rac Sitagliptin (CAS 823817-56-7)
- Sitagliptin (CAS 486460-32-6)
- Sitagliptin Impurity 10 (CAS 1253056-01-7)
- Sitagliptin Impurity 108 (CAS CATO-C4X-1144108)
- Sitagliptin Impurity 109 (CAS CATO-C4X-1144109)
- Sitagliptin Impurity 137 (CAS CATO-C4X-1144137)
Recommended Standards
- tert-Butyl 4-hydroxy-4-{[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl}piperidine-1-carboxylate (CAS 877399-39-8)
- Fmoc-Ser(PO?H?)-OH (CAS 158171-15-4)
- Ethyl 5-(4-fluorophenyl)-7-(perfluoroethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 827594-60-5)
- 3-(4-Allyl-5-(methylthio)-4H-1,2,4-triazol-3-yl)-1-(2,4-dichlorobenzyl)pyridin-2(1H)-one (CAS 477853-06-8)
- Baloxavir Impurity 56 (CAS CATO-C4X-210856)
- Vonoprazan Impurity 177 (CAS CATO-C4X-1020177)
- Melphalan Impurity 31 (CAS CATO-C4X-198831)
- 4-(4-Ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-thiol (CAS 111114-78-4)
- 3-Phenyl-1H-pyrrolo[2,3-b]pyridin-2-amine (CAS 1261633-87-7)
- N-Boc-N-methyl-3-(2-naphthyl)-L-alanine (CAS 145232-51-5)
- 3-(Bromomethyl)oxetane-3-carboxylic Acid (CAS 1802048-89-0)
- 6-Chloro-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4(3H)-one (CAS 1268612-27-6)
- 1263365-84-9 1-Cyclobutyl-2-(1,3-dioxolan-2-yl)-ethanone MFCD18433510 (CAS 1263365-84-9)
- 30003-72-6 insulin chain b oxidized (CAS 30003-72-6)
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