Sitagliptin Impurity 109 CAS CATO-C4X-1144109
| CAS No. | CATO-C4X-1144109 |
| Molecular Formula | C16H12F6N4O2 |
| Molecular Weight | 406.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 406.28 g/mol gives Sitagliptin Impurity 109 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Sitagliptin Impurity 109 (CAS CATO-C4X-1144109), a pharmacopoeial impurity reference standard (molecular formula C16H12F6N4O2, MW 406.28 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C16H12F6N4O2, Sitagliptin Impurity 109 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 406.28 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Sitagliptin Impurity 109 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H12F6N4O2 |
| Molecular Weight | 406.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Sitagliptin Standards
- Sitagliptin Impurity 108 (CAS CATO-C4X-1144108)
- Sitagliptin Impurity 137 (CAS CATO-C4X-1144137)
- Sitagliptin Impurity 4 (CAS 764667-65-4)
- Sitagliptin Impurity 23 (CAS CATO-C4X-114423)
- Sitagliptin Impurity 24 (CAS CATO-C4X-114424)
- Sitagliptin Impurity 9 (CAS 767340-03-4)
- Sitagliptin EP Impurity A (CAS 823817-55-6)
- Sitagliptin Impurity 116 (CAS 945261-50-7)
Recommended Standards
- 4-[(1E)-[(4-Chlorophenyl)imino]methyl]phenyl 4-chlorobenzene-1-sulfonate (CAS 331460-61-8)
- 2-({2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-oxoethyl}sulfanyl)pyridin-1-ium-1-olate (CAS 338785-71-0)
- Ruxolitinib Impurity 94 (CAS CATO-C4X-205894)
- 3-Iodo-4-(isopropylsulfonyl)-5-(methylthio)thiophene-2-carboxylic acid (CAS 175202-14-9)
- Bilastine Impurity 67 (CAS 1181267-38-8)
- Simvastatin EP Impurity B (CAS 145576-25-6)
- Cefoperazone Impurity 14 (CAS CATO-C4X-114914)
- (4-(1,2,2-Triphenylvinyl)phenyl)boronic acid (CAS 1227040-87-0)
- Clopidogrel Impurity 78 (CAS CATO-C4X-102978)
- 4-Butoxy-3,5-dimethylbenzoic acid (CAS 1038731-60-0)
- 8-Bromo-6-methoxyimidazo[1,5-a]pyridine (CAS 1427327-17-0)
- 2-Benzoyl-5-chlorobenzaldehyde (CAS 61077-14-3)
- [1,1'-Biphenyl]-3-thiol (CAS 51193-27-2)
- Urotensin II-Related Peptide (human, mouse, rat) (CAS 342878-90-4)
Why CATO?
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