4-(2-Fluoropyridin-3-yl)-2-(methylthio)pyrimidine CAS 945375-80-4
| CAS No. | 945375-80-4 |
| Molecular Formula | C10H8FN3S |
| Molecular Weight | 221.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(2-Fluoropyridin-3-yl)-2-(methylthio)pyrimidine.
CATO supplies 4-(2-Fluoropyridin-3-yl)-2-(methylthio)pyrimidine (CAS 945375-80-4), a certified reference material (molecular formula C10H8FN3S, MW 221.25 g/mol) for analytical method development and quality control.
The molecular framework of 4-(2-Fluoropyridin-3-yl)-2-(methylthio)pyrimidine (C10H8FN3S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8FN3S |
| Molecular Weight | 221.25 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Fluoropyridin Standards
- 4-(2-Fluoropyridin-4-yl)-2-(methylthio)pyrimidine, 97% (CAS 1453851-73-4)
- (1-(2-Fluoropyridin-4-yl)-3-methyl-1H-pyrazol-4-yl)boronic acid (CAS 2225178-82-3)
- 1,2-Bis(2-fluoropyridin-4-yl)ethane (CAS 954097-21-3)
- Methyl 5-(5-fluoropyridin-2-yl)-1,3,4-oxadiazole-2-carboxylate (CAS 1310807-73-8)
- n-(5-Fluoropyridin-2-yl)-1,3-thiazole-4-carboxamide (CAS 1498694-03-3)
- 1-(4-Fluoropyridin-2-yl)-N,N-dimethylpiperidin-4-amine 1707358-01-7 (CAS 1707358-01-7)
- 1-(5-Fluoropyridin-3-yl)-N,N-dimethylpiperidin-4-amine (CAS 1774896-70-6)
- 1-(5-Fluoropyridin-2-yl)-N,N-dimethylpiperidin-4-amine (CAS 1779120-54-5)
Recommended Standards
- 4-(2,2-Dimethylpropanoylamino)benzoic acid (CAS 56619-97-7)
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- 4-(3-(1-Hydroxyethyl)-4-methyl-4,5-dihydroisoxazol-4-yl)phenol (CAS 809238-41-3)
- Benzenesulfonic (2S)-4-(dimethylamino)-1-methylpyrrolidine-2-carboxylic anhydride (CAS 62305-75-3)
- 2-(Hydroxydiphenylmethyl)-4-methoxyphenol (CAS 936716-83-5)
- Phenyl(6-(propylamino)pyridin-3-yl)methanone (CAS 1355223-54-9)
- 1-(4-Butylphenyl)heptan-1-one (CAS 1352222-62-8)
- 3,5-Dichlorobenzimidamide (CAS 188257-67-2)
- Octahydropyrrolo[3,2-a]pyrrolizin-8(2H)-one (CAS 109941-63-1)
- 5-Amino-2-bromobenzyl bromide (CAS 1261666-44-7)
- 3-(Cyclopropylmethoxy)benzonitrile (CAS 1156169-67-3)
- 3-chloro-5-fluoro-1,7-naphthyridin-8-ol (CAS 1956385-29-7)
- D-Tyr10-Tirzepatide (CAS CATO-CPTD788922)
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