3,3-difluorocyclobutane-1-carbonyl chloride CAS 946488-78-4
| CAS No. | 946488-78-4 |
| Molecular Formula | C5H5ClF2O |
| Molecular Weight | 154.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3,3-difluorocyclobutane-1-carbonyl chloride.
3,3-difluorocyclobutane-1-carbonyl chloride (CAS 946488-78-4), molecular formula C5H5ClF2O and molecular weight 154.54 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 3,3-difluorocyclobutane-1-carbonyl chloride (C5H5ClF2O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 2.0, corresponding to approximately 2 ring(s) or double-bond equivalent(s). With a molecular weight of 154.54 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3,3-difluorocyclobutane-1-carbonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5ClF2O |
| Molecular Weight | 154.54 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Stable under recommended storage conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
Related difluorocyclobutane Standards
- (3,3-difluorocyclobutane-1,1-diyl)dimethanamine (CAS 1446422-58-7)
- ethyl 3,3-difluorocyclobutane-1-carboxylate (CAS 681128-38-1)
- 3,3-Difluorocyclobutane-1-sulfonamide (CAS 2171856-86-1)
- 2,2-difluorocyclobutane-1-carboxylic acid (CAS 1150518-74-3)
- (R)-2,2-Difluorocyclobutane-1-carboxylic acid (CAS 2742942-02-3)
- (S)-2,2-Difluorocyclobutane-1-carboxylic acid (CAS 2750509-66-9)
- 1,3-difluorocyclobutane-1-carboxylic acid (CAS 2091263-77-1)
- 3,3-difluorocyclobutane-1-carboxamide (CAS 86770-82-3)
Recommended Standards
- 2-chloro-1-(2,2-difluorocyclopropyl)ethanone (CAS 2301036-57-5)
- 5-Chloro-2-hydroxynicotinonitrile (CAS 1048913-62-7)
- 2,3-Difluoro-1-Methylcyclopropanecarbonyl Chloride (CAS 315690-85-8)
- 4-Chlorooxazolo[4,5-c]pyridine (CAS 1159829-15-8)
- 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-3-methylbutanoic acid (CAS 957513-81-4)
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- 5-Bromo-2,4-dichlorobenzoic acid (CAS 791137-20-7)
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