N-{3-[2-Amino-4-(trifluoromethyl)phenoxy]-phenyl}acetamide CAS 946715-45-3
| CAS No. | 946715-45-3 |
| Molecular Formula | C15H13F3N2O2 |
| Molecular Weight | 310.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of N-{3-[2-Amino-4-(trifluoromethyl)phenoxy]-phenyl}acetamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
N-{3-[2-Amino-4-(trifluoromethyl)phenoxy]-phenyl}acetamide (CAS 946715-45-3) is a high-purity analytical reference standard with the molecular formula C15H13F3N2O2 and a molecular weight of 310.27 g/mol.
The molecular framework of N-{3-[2-Amino-4-(trifluoromethyl)phenoxy]-phenyl}acetamide (C15H13F3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-{3-[2-Amino-4-(trifluoromethyl)phenoxy]-phenyl}acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H13F3N2O2 |
| Molecular Weight | 310.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- Methyl 4-{[2-amino-4-(trifluoromethyl)phenyl]amino}benzoate (CAS 1281348-84-2)
- Ethyl 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-(2-ethoxy-2-oxoethyl)-1H-1,2,3-triazole-4-carboxylate (CAS 313952-92-0)
- N-(3-(4-amino-2-(trifluoromethyl)phenoxy)phenyl)acetamide (CAS 946740-70-1)
- N-{3-[4-Amino-3-(trifluoromethyl)phenoxy]-phenyl}acetamide (CAS 946698-12-0)
- 4-Amino-7-(b-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine-5-carboxylic acid (CAS 18418-00-3)
- 2-Amino-4-(4-methoxyphenyl)-7-methyl-5-oxo-4H,5H-pyrano[4,3-b]pyran-3-carbonitrile (CAS 194282-76-3)
- 2-Amino-4-(3-methoxyphenyl)-7-methyl-5-oxo-4H,5H-pyrano[4,3-b]pyran-3-carbonitrile (CAS 300388-42-5)
- 2-Amino-6-(hydroxymethyl)-8-oxo-4-(m-tolyl)-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile (CAS 876710-04-2)
Recommended Standards
- N-[(Pyridin-4-yl)methyl]-4-(2,2,2-trifluoroethoxy)benzamide (CAS 866153-58-4)
- N,N-dimethyl-4-(4-(trifluoromethyl)benzoyl)-1H-pyrrole-2-carboxamide (CAS 241147-00-2)
- Niflumic Acid Ethyl Ester (CAS 51703-19-6)
- N,N-dimethyl-4-(2-(trifluoromethyl)benzoyl)-1H-pyrrole-2-carboxamide (CAS 477852-39-4)
- 3-Amino-2-phenylpyridine (CAS 101601-80-3)
- 1738AE 367501-07-3 4-(2-Chloro-4-fluorophenoxy)piperidine C11H13ClFNO (CAS 367501-07-3)
- 3-Bromo-5-methylisonicotinic acid (CAS 1211588-92-9)
- 3-Bromo-4-(prop-2-en-1-yloxy)benzaldehyde (CAS 724746-23-0)
- 2-Cyclopentyl-N-((5-(thiophen-2-yl)isoxazol-3-yl)methyl)acetamide (CAS 946344-94-1)
- (S)-2-Amino-3-(4-cyano-1H-indol-3-yl)propanoic acid (CAS 1132749-42-8)
- Ethyl (3R,4S)-4-hydroxypyrrolidine-3-carboxylate (CAS 2253105-21-2)
- 6-Amino-2-fluoronicotinonitrile (CAS 1445962-29-7)
- 6-chloro-3-iodo-pyrazolo[1,5-a]pyrimidine (CAS 2306264-38-8)
- Semaglutide impurity 64 (CAS CATO-C4X-222664)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com