4-(3-Pyridinyloxy)-2-(trifluoromethyl)aniline CAS 946741-55-5
| CAS No. | 946741-55-5 |
| Molecular Formula | C12H9F3N2O |
| Molecular Weight | 254.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-(3-Pyridinyloxy)-2-(trifluoromethyl)aniline (CAS 946741-55-5) is a high-purity analytical reference standard with the molecular formula C12H9F3N2O and a molecular weight of 254.21 g/mol.
4-(3-Pyridinyloxy)-2-(trifluoromethyl)aniline (C12H9F3N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H9F3N2O |
| Molecular Weight | 254.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 4-(2-Trifluoromethyl-pyridin-4-yloxy)-phenylamine (CAS 630125-71-2)
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- 1,3-Dibromo-2-(bromomethyl)benzene (CAS 93701-32-7)
- 2-Amino-4-phenethylthiazolo[4,5-d]pyrimidine-5,7(4H,6H)-dione (CAS 898131-78-7)
- (E)-1,4-Bis((5,6-diphenyl-1,2,4-triazin-3-yl)thio)but-2-ene (CAS 5856-32-6)
- 3,3',5,5'-Tetramethyl-1H,1'H-4,4'-bipyrazole (CAS 4054-67-5)
- Ethyl 3-(4-methoxybenzamido)-2-oxo-6-phenyl-2H-pyran-5-carboxylate (CAS 338404-95-8)
- Semaglutide impurity 83 (CAS CATO-C4X-222683)
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