4-((5-(Trifluoromethyl)pyridin-2-yl)oxy)aniline CAS 71422-81-6
| CAS No. | 71422-81-6 |
| Molecular Formula | C12H9F3N2O |
| Molecular Weight | 254.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-((5-(Trifluoromethyl)pyridin-2-yl)oxy)aniline (C12H9F3N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
4-((5-(Trifluoromethyl)pyridin-2-yl)oxy)aniline (CAS 71422-81-6), molecular formula C12H9F3N2O and molecular weight 254.21 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-((5-(Trifluoromethyl)pyridin-2-yl)oxy)aniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9F3N2O |
| Molecular Weight | 254.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1977 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Trifluoromethyl Standards
- 4-((3-(Trifluoromethyl)pyridin-2-yl)oxy)aniline (CAS 1086378-47-3)
- 4-((6-(Trifluoromethyl)pyridin-2-yl)oxy)aniline (CAS 1086378-51-9)
- 2-[7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]acetic acid (CAS 1160245-89-5)
- (6-(Trifluoromethyl)-[2,4'-bipyridin]-3-yl)methanol (CAS 1227573-18-3)
- 6-Methyl-2-(4-(trifluoromethyl)phenyl)pyrimidin-4-ol (CAS 125903-90-4)
- 2-(3-(Trifluoromethyl)phenyl)pyrimidine-5-methanol (CAS 1261480-83-4)
- 2-Methyl-4-[3-(trifluoromethyl)-1H-pyrazol-1-yl]benzaldehyde (CAS 1270876-85-1)
- 1-{[4-(trifluoromethyl)phenyl]methyl}-1H-pyrazole-4-carbaldehyde (CAS 1275308-13-8)
Recommended Standards
- 3-Hydrazinyl-6-(3-(trifluoromethyl)phenyl)pyridazine (CAS 76970-16-6)
- 4-(2-Trifluoromethyl-pyridin-4-yloxy)-phenylamine (CAS 630125-71-2)
- 2-Hydrazinyl-4-phenyl-6-(trifluoromethyl)pyrimidine (CAS 869952-73-8)
- 4-(3-Pyridinyloxy)-2-(trifluoromethyl)aniline (CAS 946741-55-5)
- (S)-4-Amino-1-methylpyrrolidin-2-one (CAS 770706-26-8)
- 2-Acetylquinazolin-4(3H)-one (CAS 17244-28-9)
- 2-(2-Chloroallyl)-5-methylthiophene (CAS 1314902-57-2)
- (4-(Difluoromethyl)-6-fluoro-3-(trifluoromethyl)pyridin-2-yl)methanol (CAS 1804855-03-5)
- Piretanide-d4 (Major) (CAS 1246816-90-9)
- (2-(Hydroxymethyl)pyrrolidin-1-yl)(phenyl)methanone (CAS 72351-42-9)
- 4-amino-2-(2-aminoethyl)butanoic acid dihydrochloride (CAS 1384651-82-4)
- 1-(6-Methyl-1,2,3,4-tetrahydroquinolin-5-yl)thiourea (CAS 691891-04-0)
- 4,5-Difluoro-2-iodoaniline (CAS 847685-01-2)
- [3-31]-Semaglutide D (CAS C152H230N42O47)
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