Atorvastatin Calcium EP Impurity I CAS 947249-30-1
| CAS No. | 947249-30-1 |
| Molecular Formula | C40H47FN2O5 |
| Molecular Weight | 654.81 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Atorvastatin Calcium EP Impurity I (CAS 947249-30-1, C40H47FN2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Atorvastatin Calcium EP Impurity I (C40H47FN2O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 18.0, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 654.81 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C40H47FN2O5 |
| Molecular Weight | 654.81 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Atorvastatin Standards
- Atorvastatin Impurity 76 (CAS 1099474-28-8)
- Atorvastatin EP Impurity I (CAS 125971-95-1)
- Atorvastatin Impurity 24 (CAS 472967-95-6)
- Atorvastatin Impurity 66 (CAS 1105067-90-0)
- Atorvastatin 3-Isopropyl Ether tert-Butyl Ester (CAS 1797009-04-1)
- Atorvastatin Impurity 65 (CAS 1105067-91-1)
- Atorvastatin Impurity 67 (CAS 693793-87-2)
- Atorvastatin Impurity 74 (CAS CATO-C4X-113274)
Recommended Standards
- 4-(1H-Indol-3-yl)butan-1-ol (CAS 3364-37-2)
- Filipin III (CAS 480-49-9)
- Bismuth selenide (CAS 12068-69-8)
- (3S,4R,5S,6S)-4,5-Bis(benzyloxy)-6-((benzyloxy)methyl)-2-(p-tolylthio)tetrahydro-2h-pyran-3-yl4-oxopentanoate (CAS 350600-54-3)
- Rosuvastatin Impurity 230 (CAS CATO-C4X-1169230)
- Obeticholic Acid Impurity 45 (CAS CATO-C4X-115345)
- Vonoprazan Impurity 103 (CAS CATO-C4X-1020103)
- 6-Bromo-2-(pyridin-3-yl)-4H-chromen-4-one (CAS 1218-81-1)
- N-Fmoc-N-methyl-O-(3-methylbutyl)-L-Serine (CAS 2255321-12-9)
- 2-(2-Chloro-1H-benzo[d]imidazol-5-yl)acetic acid (CAS 1499592-63-0)
- 2-(5-((2,5-Dimethylbenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyridine (CAS 573948-00-2)
- 2-(4-Bromo-3-fluorophenyl)-5-methyl-1,3,4-oxadiazole (CAS 1093064-67-5)
- 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid (CAS 186519-92-6)
- [3-31]-Semaglutide D (Sodium salt) (CAS CATO-C4X-2226119)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com