2-Chloro-3-(3-chloropropyl)-6-fluoroquinoline CAS 948294-65-3
| CAS No. | 948294-65-3 |
| Molecular Formula | C12H10Cl2FN |
| Molecular Weight | 258.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Chloro-3-(3-chloropropyl)-6-fluoroquinoline is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 2-Chloro-3-(3-chloropropyl)-6-fluoroquinoline (CAS 948294-65-3), a certified reference material (molecular formula C12H10Cl2FN, MW 258.12 g/mol) for analytical method development and quality control.
The molecular framework of 2-Chloro-3-(3-chloropropyl)-6-fluoroquinoline (C12H10Cl2FN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-3-(3-chloropropyl)-6-fluoroquinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H10Cl2FN |
| Molecular Weight | 258.12 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-3-(3-chloropropyl)-7-fluoroquinoline (CAS 948290-17-3)
- 2-Chloro-N-(2-chlorobenzyl)-N-cyclopropylacetamide (CAS 1092295-05-0)
- 2-Chloro-N-(3-chlorobenzyl)-N-cyclopropylacetamide (CAS 1175651-36-1)
- 2-Chloro-N-(4-chlorobenzyl)-N-cyclopropylacetamide (CAS 1177199-20-0)
- 5-(3-Chloro-4-methoxyphenyl)-2-(chloromethyl)oxazole (CAS 1215990-56-9)
- (E)-5-chloro-3-(4-chlorobut-2-en-1-yl)benzo[d]oxazol-2(3H)-one (CAS 866150-27-8)
- 2-Chloro-N-(3-chloro-4-fluorophenyl)pyrimidin-4-amine (CAS 919200-71-8)
- 2-chloro-3-(chloromethyl)-7-(methylthio)quinoline (CAS 794582-34-6)
Recommended Standards
- 2-Bromo-6,7-dihydrospiro[pyrazolo[5,1-c][1,4]oxazine-4,3'-pyrrolidine] (CAS 2813866-67-8)
- 2-Bromo-5,5-dimethyl-5,6-dihydro-4H-pyrazolo[1,5-d][1,4]diazepin-7(8H)-one (CAS 2246364-05-4)
- 2-Methyl-2H-indazole-4-boronic Acid Pinacol Ester (CAS 885698-95-3)
- 2-Bromo-1-(2-(pyrrolidin-1-yl)-1H-imidazol-4-yl)ethanone (CAS 88723-66-4)
- 2-[(5-Amino-1,3,4-thiadiazol-2-yl)thio]-N-cyclopropylacetamide (CAS 876532-11-5)
- spiro[3.3]heptane-2-carbonitrile (CAS 2105526-91-6)
- 1-Methyl-1-(3-methylbenzyl)guanidine sulfate (CAS 1185479-32-6)
- 1,2,4,5-Tetrazine-3,6-dicarboxylicacid, 3,6-dimethyl ester 2166-14-5 CTK4E7441 (CAS 2166-14-5)
- 2-Amino-4-methyl-5-(piperidine-1-carbonyl)thiophene-3-carbonitrile (CAS 313971-49-2)
- N-((2-Methylquinolin-4-yl)methyl)acetamide (CAS 42182-60-5)
- (S)-Methyl 5-bromo-1,2,3,4-tetrahydroisoquinoline-3-carboxylate (CAS 2381362-37-2)
- Empagliflozin Impurity N7 (CAS 872980-38-6)
- 2-(3-(1,1,2,2-Tetrafluoroethyl)-1H-pyrazol-5-yl)phenol (CAS 378754-97-3)
- Semaglutide Impurity 10 (CAS CATO-C4X-222610)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com