(2-Chloro-5-fluoropyridin-4-yl)boronic acid CAS 951677-47-7
| CAS No. | 951677-47-7 |
| Molecular Formula | C5H4BClFNO2 |
| Molecular Weight | 175.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies (2-Chloro-5-fluoropyridin-4-yl)boronic acid (CAS 951677-47-7), a certified reference material (molecular formula C5H4BClFNO2, MW 175.35 g/mol) for analytical method development and quality control.
(2-Chloro-5-fluoropyridin-4-yl)boronic acid (C5H4BClFNO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (2-Chloro-5-fluoropyridin-4-yl)boronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H4BClFNO2 |
| Molecular Weight | 175.35 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 5-Chloro-2-fluoro-4-pyridineboronic Acid (CAS 1034659-38-5)
- 6-Chloro-5-fluoropyridine-3-boronic Acid (CAS 1072946-66-7)
- 3-Chloro-2-fluoropyridine-4-boronic Acid (CAS 1217500-55-4)
- (2-Chloro-4-fluoropyridin-3-yl)boronic acid (CAS 1383970-43-1)
- 3-Chloro-5-fluoropyridine-4-boronic acid (CAS 1444025-19-7)
- (2-Chloro-6-fluoropyridin-3-yl)boronic acid (CAS 1541206-12-5)
- (2-Chloro-5-fluoropyridin-3-yl)boronic acid (CAS 913373-43-0)
- (2-Chloro-6-fluoropyridin-4-yl)boronic acid (CAS 2225176-58-7)
Recommended Standards
- (4-Chloro-2-fluoropyridin-3-yl)boronic acid (CAS 2096339-11-4)
- (6-Chloro-4-fluoropyridin-3-yl)boronic acid (CAS 2096341-49-8)
- 2-Chloro-3-fluoropyridine-4-boronic Acid (CAS 937595-71-6)
- 2,6-Difluoro-3-pyridineboronic Acid (CAS 136466-94-9)
- 4-Chlorophenyl 4-methoxypyridin-2-ylcarbamate (CAS 1984037-81-1)
- 5-Bromo-4-methoxy-2-(piperazin-1-yl)pyrimidine (CAS 885267-38-9)
- Bis(3-methylphenyl)methanamine (CAS 858453-29-9)
- N-(9H-Purin-6-yl)propionamide (CAS 37385-05-0)
- 3-Chloropyridine-2,5-dicarboxylic acid (CAS 106014-20-4)
- Methyl 5-formylthiophene-3-carboxylate (CAS 67808-66-6)
- 3'-(Ethylcarbamoyl)-3-fluoro-[1,1'-biphenyl]-2-carboxylic acid (CAS 1261908-77-3)
- Methyl 4-acetamido-5-amino-2-methoxybenzoate (CAS 77495-40-0)
- 3-Methylfuro[3,2-b]pyridine (CAS 107096-11-7)
- Retatrutide (CAS 2381089-83-2)
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