3-(3,5-Difluorophenyl)-7-hydroxy-2H-chromen-2-one CAS 951957-81-6
| CAS No. | 951957-81-6 |
| Molecular Formula | C15H8F2O3 |
| Molecular Weight | 274.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies 3-(3,5-Difluorophenyl)-7-hydroxy-2H-chromen-2-one (CAS 951957-81-6), a certified reference material (molecular formula C15H8F2O3, MW 274.22 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system, 3-(3,5-Difluorophenyl)-7-hydroxy-2H-chromen-2-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 274.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C15H8F2O3 |
| Molecular Weight | 274.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
Related Difluorophenyl Standards
- 1-(3,4-Difluorophenyl)-1H-benzo[d]imidazole-5-carboxylic acid (CAS 442531-67-1)
- 2-((2,4-Difluorophenyl)amino)-4H-benzo[d][1,3]oxazin-4-one (CAS 477854-01-6)
- 2-(3,4-Difluorophenyl)-1H-benzimidazole-6-carboxylic acid (CAS 870115-12-1)
- 3-(3-(2,6-Difluorophenyl)-1,2,4-oxadiazol-5-yl)pyridin-2-amine (CAS 1708168-88-0)
- (E)-2-(3-((2,6-difluorophenyl)amino)-1-(dimethylamino)allylidene)malononitrile (CAS 338773-86-7)
- 1421262-35-2 2-(3,4-Difluorophenyl)-4-(4-pyridyl)thiazole MFCD22683012 (CAS 1421262-35-2)
- 1-(2,4-Difluorophenyl)-3-(2,3-dimethylphenyl)propan-1-one (CAS 898793-33-4)
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Recommended Standards
- 3-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yl)oxy)-4H-pyran-4-one (CAS 59219-76-0)
- 3-(5,6-Difluorobenzofuran-2-yl)benzoic acid (CAS 835595-08-9)
- 2-(Acetoxymethyl)-5-oxotetrahydrofuran-3,4-diyl diacetate (CAS 394739-29-8)
- 5-(2-Triflluoromethylphenyl)-1,3,4-thiadiazole-2-carboxylic acid (CAS 1993310-10-3)
- 1-Ethyl-2-(hydroxymethyl)-4-tosylpiperazine-2-carbonitrile (CAS 2201785-68-2)
- 2-(4-hydroxyphenyl)propanedial (CAS 554453-78-0)
- 2-((1-(2-Amino-2-oxoethyl)-5-(hydroxymethyl)-1H-imidazol-2-yl)thio)-N-(3-methoxyphenyl)acetamide (CAS 921503-04-0)
- 6-Fluoro-2-piperazin-1-yl-benzooxazole (CAS 1246609-07-3)
- 5-(2-Cyanopropan-2-yl)nicotinic acid (CAS 878742-36-0)
- Dibenzo[a,i]pyrene[5,8]quinone (CAS 3302-52-1)
- Difluprednate Impurity 3 (CAS 1234557-20-0)
- 2-Amino-4-(4-fluorophenyl)thiophene-3-carboxamide (CAS 61019-24-7)
- 3-Fluoro-5-(trifluoromethoxy)benzamide (CAS 1352999-12-2)
- Tirzepatide Impurity 46 (CAS CATO-C4X-324046)
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