3-(3,4-Difluorophenoxy)azetidine CAS 954220-76-9
| CAS No. | 954220-76-9 |
| Molecular Formula | C9H9F2NO |
| Molecular Weight | 185.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(3,4-Difluorophenoxy)azetidine (CAS 954220-76-9), molecular formula C9H9F2NO and molecular weight 185.17 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 3-(3,4-Difluorophenoxy)azetidine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 185.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(3,4-Difluorophenoxy)azetidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H9F2NO |
| Molecular Weight | 185.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluorophenoxy Standards
- 3-(2,3-Difluorophenoxy)azetidine (CAS 1211876-03-7)
- 3-(2,6-Difluorophenoxy)azetidine (CAS 1211876-06-0)
- 3-(2,5-Difluorophenoxy)azetidine (CAS 1263378-42-2)
- 3-(3,5-Difluorophenoxy)azetidine (CAS 1263378-82-0)
- 3-(2,4-Difluorophenoxy)azetidine (CAS 954225-05-9)
- 1-(3,4-Difluorophenoxy)propan-2-one (CAS 1153999-83-7)
- (S)-2-((3,4-Difluorophenoxy)methyl)oxirane (CAS 144574-27-6)
- 2-((2,4-Difluorophenoxy)methyl)oxirane (CAS 169286-61-7)
Recommended Standards
- 3-(3,5-Difluorophenyl)isoxazolidine (CAS 2360950-32-7)
- 2-Amino-1-(3,4-difluorophenyl)propan-1-one (CAS 799240-65-6)
- 4-(Dimethylamino)-2,5-difluorobenzaldehyde (CAS 99357-41-2)
- 2,6-Difluoro-N,N-dimethylbenzamide (CAS 81652-57-5)
- 2,3-Dichloro-5-(difluoromethoxy)benzyl bromide (CAS 1806353-20-7)
- (2-aminopropoxy)benzene hydrochloride (CAS 1519-94-4)
- 3-Cyano-N-((tetrahydrofuran-2-yl)methyl)benzamide (CAS 1008386-47-7)
- 3,5-Difluoro-4'-propyl-1,1'-biphenyl (CAS 137528-87-1)
- 2-Oxoindoline-5-boronic Acid Pinacol Ester (CAS 837392-64-0)
- tert-Butyl (S)-2-acetoxypropanoate (CAS 120444-05-5)
- 5-(Trifluoromethyl)-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine hydrochloride (CAS 2193065-03-9)
- Cyetpyrafen (CAS 1253429-01-4)
- N'-methyl-N'-(2-(methylthio)quinazolin-4-yl)thiophene-2-carbohydrazide (CAS 341968-19-2)
- C-Peptide（dog） (CAS 39016-05-2)
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