8-Bromo-2-chloroquinazolin-4-amine CAS 956100-62-2
| CAS No. | 956100-62-2 |
| Molecular Formula | C8H5BrClN3 |
| Molecular Weight | 258.50 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
8-Bromo-2-chloroquinazolin-4-amine (CAS 956100-62-2), molecular formula C8H5BrClN3 and molecular weight 258.50 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution, 8-Bromo-2-chloroquinazolin-4-amine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 258.50 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5BrClN3 |
| Molecular Weight | 258.50 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 3 |
Related Bromo Standards
- 3-Bromo-7-chloroquinolin-6-ol (CAS 1009811-89-5)
- 4-Bromo-7-chloroisoquinolin-1(2H)-one (CAS 1028252-13-2)
- 6-Bromo-7-chloro-1(2H)-isoquinolinone (CAS 1036712-57-8)
- 6-Bromo-3-chloroquinoxalin-2-amine (CAS 1083181-47-8)
- 7-Bromo-5-chloro-1H-indole-3-carbaldehyde (CAS 1100217-75-1)
- 7-Bromo-2-chloroquinazolin-4-amine (CAS 1107695-08-8)
- 5-Bromo-2-chloroquinazolin-4-amine (CAS 1107695-10-2)
- 6-Bromo-8-chloroquinolin-4(1H)-one (CAS 1153084-25-3)
Recommended Standards
- 7-Bromo-8-chloroquinolin-2(1H)-one (CAS 2021809-76-5)
- 8-Bromo-3-chloroisoquinolin-5-ol (CAS 2660256-28-8)
- 7-Bromo-6-chloroquinazolin-4-amine (CAS 2385786-28-5)
- Hydroxychloroquine RC 2 (CAS 860715-45-3)
- 4-Chloro-2-(3-methoxyphenyl)-5-(methylamino)pyridazin-3(2H)-one (CAS 84607-75-0)
- (s)-2-Amino-2-(4-bromo-3-nitrophenyl)ethan-1-ol (CAS 1212861-41-0)
- Methyl 3,5-difluoro-4-nitrobenzoate (CAS 1123172-87-1)
- trans-3-Methylpiperidin-4-ol (CAS 227030-11-7)
- oxan-3-amine hydrochloride (CAS 675112-58-0)
- 4-Bromo-1-butoxy-2-fluorobenzene (CAS 54509-63-6)
- 1-(Azetidin-3-yl)-2-methylpropan-1-ol (CAS 1257294-25-9)
- 4-Hydroxy-3,5-diiodobenzohydrazide (CAS 89011-17-6)
- Pyridine (CAS 110-86-1)
- D-Ile17-Tirzepatide (CAS CATO-CPTD788917)
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