5-(Trifluoromethyl)picolinonitrile CAS 95727-86-9
| CAS No. | 95727-86-9 |
| Molecular Formula | C7H3F3N2 |
| Molecular Weight | 172.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(Trifluoromethyl)picolinonitrile.
5-(Trifluoromethyl)picolinonitrile (CAS 95727-86-9), molecular formula C7H3F3N2 and molecular weight 172.11 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrile group, fluorine substitution, an aromatic ring system, 5-(Trifluoromethyl)picolinonitrile is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 172.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(Trifluoromethyl)picolinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H3F3N2 |
| Molecular Weight | 172.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Trifluoromethyl Standards
- 3-(Trifluoromethyl)isonicotinonitrile (CAS 1214383-56-8)
- 2-(Trifluoromethyl)isonicotinonitrile (CAS 916210-02-1)
- 2-(Trifluoromethyl)nicotinonitrile (CAS 870066-15-2)
- 6-(Trifluoromethyl)nicotinonitrile (CAS 216431-85-5)
- 6-(Trifluoromethyl)pyridine-2-carbonitrile (CAS 887583-52-0)
- 2-(Trifluoromethyl)-1,3-oxathiolan-5-one (CAS 79413-31-3)
- 1-(Trifluoromethyl)-2-vinylbenzene (CAS 395-45-9)
- 3-(Trifluoromethyl)tetrahydrothiophen-3-ol (CAS 1247860-37-2)
Recommended Standards
- 4-fluoro-2,3-dihydroxybenzoic acid (CAS 823797-30-4)
- 5-Fluoro-2,6-dihydroxynicotinamide (CAS 71765-03-2)
- 4-Ethynyl-2-(trifluoromethyl)pyrimidine (CAS 37972-21-7)
- 5-Fluoro-4-methoxy-2-nitropyridine (CAS 2306270-56-2)
- 2-((6-Amino-9H-purin-8-yl)thio)propanoic acid (CAS 330983-00-1)
- Ethyl 4-bromo-2-fluoro-3-hydroxybenzoate (CAS 1807191-25-8)
- 3-Bromo-5-(2-methoxyethoxy)pyridine (CAS 181585-07-9)
- 2-(3-Methyl-1H-pyrazol-1-yl)propanamide (CAS 1171977-37-9)
- N,N'-(Ethane-1,2-diyl)bis(3-methylbenzenesulfonamide) (CAS 793713-92-5)
- Zeniplatin (CAS 111490-36-9)
- 1',2'-dihydrospiro[azetidine-3,3'-pyrrolo[2,3-b]pyridine]-2'-one (CAS 1638768-22-5)
- 5-(Pyridin-3-yl)isophthalic acid (CAS 1264068-70-3)
- 7-Chloro-2-iodoimidazo[1,2-a]pyridine (CAS 1384265-42-2)
- Tau Peptide (295-309) trifluoroacetate salt (CAS 330456-46-7)
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