Fluticasone Propionate EP Impurity I CAS 960071-64-1
| CAS No. | 960071-64-1 |
| Molecular Formula | C48H58F4O10S3 |
| Molecular Weight | 967.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Fluticasone Propionate EP Impurity I (CAS 960071-64-1), a pharmacopoeial impurity reference standard (molecular formula C48H58F4O10S3, MW 967.16 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Fluticasone Propionate EP Impurity I (C48H58F4O10S3) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 18.0, corresponding to approximately 18 ring(s) or double-bond equivalent(s). With a molecular weight of 967.16 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C48H58F4O10S3 |
| Molecular Weight | 967.16 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Sulfur Atoms | 3 |
Related Fluticasone Standards
- Fluticasone Impurity 36 (CAS 192191-51-8)
- Fluticasone Propionate EP Impurity H (CAS 201812-64-8)
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