4,6-Dichloro-5-fluoro-2-(trifluoromethyl)pyrimidine CAS 96819-55-5
| CAS No. | 96819-55-5 |
| Molecular Formula | C5Cl2F4N2 |
| Molecular Weight | 234.97 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 4,6-Dichloro-5-fluoro-2-(trifluoromethyl)pyrimidine (CAS 96819-55-5), a certified reference material (molecular formula C5Cl2F4N2, MW 234.97 g/mol) for analytical method development and quality control.
The molecular framework of 4,6-Dichloro-5-fluoro-2-(trifluoromethyl)pyrimidine (C5Cl2F4N2) is characterized by a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4,6-Dichloro-5-fluoro-2-(trifluoromethyl)pyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5Cl2F4N2 |
| Molecular Weight | 234.97 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichloro Standards
- 2,4-Dichloro-5-fluoro-6-(trifluoromethyl)pyrimidine (CAS 96819-53-3)
- 3,3-Dichloro-2-(phosphonomethyl)acrylic acid (CAS 122279-84-9)
- 1,2-Dichloro-3,3,3-trifluoro-2-(trifluoromethyl)-propane (CAS 138690-25-2)
- 2,2-Dichloro-1,1,1,4,4,4-hexafluorobutane (CAS 162462-08-0)
- 2,3-Dichloro-1,1,1,4,4,4-hexafluorobutane (CAS 384-54-3)
- 2,4-dichloro-5-nitrobenzamide (CAS 101421-03-8)
- 2,4-Dichloro-6-nitrobenzamide (CAS 1803726-83-1)
- 2,3-Dichloro-4-nitrobenzamide (CAS 1803805-60-8)
Recommended Standards
- 2-CHLORO-1,1,2,2-TETRAFLUORO-ETHANESULFONYL CHLORIDE (CAS 89740-40-9)
- (6-Ethoxy-5-(trifluoromethyl)pyridin-3-yl)boronic acid (CAS 849934-85-6)
- 4-Bromo-5-nitro-1h-pyrrole-2-carboxylic acid (CAS 1146289-91-9)
- (2-Ethoxy-5-(trifluoromethyl)pyridin-3-yl)boronic acid (CAS 1218790-66-9)
- 2-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)acetic acid (CAS 1048920-83-7)
- 4-(aminomethyl)-1-benzylpiperidin-4-ol (CAS 23804-68-4)
- Calcitonin,pro- (CAS 56645-65-9)
- 5,6-difluoro-1H-indole-3-carbaldehyde (CAS 260267-07-0)
- 2-[(pyridin-2-yl)methoxy]aniline dihydrochloride (CAS 1185299-37-9)
- Tert-butyl (1-(pyrimidin-4-yl)piperidin-4-yl)carbamate (CAS 596817-39-9)
- tert-Butyl (4-hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)carbamate (CAS 1384312-65-5)
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