4-Chloro-3-nitrobenzenesulfonamide CAS 97-09-6
| CAS No. | 97-09-6 |
| Molecular Formula | C6H5ClN2O4S |
| Molecular Weight | 236.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-3-nitrobenzenesulfonamide.
4-Chloro-3-nitrobenzenesulfonamide (CAS 97-09-6), molecular formula C6H5ClN2O4S and molecular weight 236.63 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Chloro-3-nitrobenzenesulfonamide (C6H5ClN2O4S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5ClN2O4S |
| Molecular Weight | 236.63 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 4-Chloro-6-fluoro-7-methoxyquinoline-3-carbonitrile (CAS 1017788-78-1)
- 4-Chloro-6-fluoro-8-methoxyquinoline-3-carbonitrile (CAS 1247810-29-2)
- 4-Chloro-2-nitrobenzene-1-sulfonamide (CAS 13852-81-8)
- 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonitrile 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonitrile 175204-41-8 (CAS 175204-41-8)
- 4-Chloro-8-fluoro-6-methoxyquinoline-3-carbonitrile (CAS 1823500-08-8)
- 2-Chloro-4-nitrobenzenesulfonamide (CAS 31150-99-9)
- 2-Chloro-5-nitrobenzenesulfonamide (CAS 96-72-0)
- 2-Chloro-5-sulfobenzoic acid (CAS 40284-70-6)
Recommended Standards
- 4-Amino-3-nitrobenzene-1-sulfonyl chloride (CAS 84202-56-2)
- 4-Chloro-3-sulfobenzoic acid (Bumetanide Impurity) (CAS 755698-62-5)
- 4-(Chlorosulfonyl)-2-hydroxybenzoic acid (CAS 98273-15-5)
- 4-Chloro-7-fluoro-6-methoxyquinoline-3-carbonitrile (CAS 622369-40-8)
- N1-Isopropylethane-1,2-diamine dihydrochloride (CAS 64670-89-9)
- N,N-Diethylpyrimidine-4-carboxamide (CAS 90648-34-3)
- 220141-69-5 1-(2,4,6-Trifluorophenyl)propan-1-one DTXSID50380743 (CAS 220141-69-5)
- 3-(4-Chlorobenzyl)-1,3-thiazolidine-2,4-dione (CAS 103027-70-9)
- 5-Chloro-6-(dimethylamino)pyridin-3-ylboronic acid (CAS 1704121-36-7)
- 3,3',3'',4,4',4''-Hexahexyl-2,2':5',2''-terthiophene (CAS CATO-CIM-105981)
- 4-Chloro-3-nitrocinnoline (CAS 408353-00-4)
- 1-(2-(Ethylthio)-1-methyl-1H-imidazol-5-yl)-N-(4-fluorophenyl)methanimine (CAS 303986-82-5)
- 4-Fluoro-3-(methylsulfonyl)aniline (CAS 914636-44-5)
- Semaglutide Impurity 152 xTFA (CAS CATO-C4X-2226152)
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