4-Chloro-3-sulfobenzoic acid (Bumetanide Impurity) CAS 755698-62-5
| CAS No. | 755698-62-5 |
| Molecular Formula | C7H5ClO5S |
| Molecular Weight | 236.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-Chloro-3-sulfobenzoic acid (Bumetanide Impurity) is closely related to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-Chloro-3-sulfobenzoic acid (Bumetanide Impurity) (CAS 755698-62-5), a pharmacopoeial impurity reference standard (molecular formula C7H5ClO5S, MW 236.63 g/mol) used for the identification and quantification of trace impurities in APIs.
4-Chloro-3-sulfobenzoic acid (Bumetanide Impurity) (C7H5ClO5S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), 4-Chloro-3-sulfobenzoic acid (Bumetanide Impurity) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5ClO5S |
| Molecular Weight | 236.63 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 4-Chloro-6-fluoro-7-methoxyquinoline-3-carbonitrile (CAS 1017788-78-1)
- 4-Chloro-6-fluoro-8-methoxyquinoline-3-carbonitrile (CAS 1247810-29-2)
- 4-Chloro-2-nitrobenzene-1-sulfonamide (CAS 13852-81-8)
- 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carbonitrile 3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarbonitrile 175204-41-8 (CAS 175204-41-8)
- 4-Chloro-8-fluoro-6-methoxyquinoline-3-carbonitrile (CAS 1823500-08-8)
- 2-Chloro-4-nitrobenzenesulfonamide (CAS 31150-99-9)
- 2-Chloro-5-nitrobenzenesulfonamide (CAS 96-72-0)
- 2-Chloro-5-sulfobenzoic acid (CAS 40284-70-6)
Recommended Standards
- 4-Chloro-3-nitrobenzenesulfonamide (CAS 97-09-6)
- 4-Chloro-7-fluoro-6-methoxyquinoline-3-carbonitrile (CAS 622369-40-8)
- 4-Amino-3-nitrobenzene-1-sulfonyl chloride (CAS 84202-56-2)
- 4-Chloro-8-fluoro-7-methoxyquinoline-3-carbonitrile (CAS 2150766-07-5)
- Cefixime Impurity 70 (CAS CATO-C4X-113970)
- Brivaracetam impurity 95 (CAS 2052297-73-9)
- Sildenafil Impurity 248 (CAS 139756-30-2)
- 1-piperidin-4-yl-1H-benzimidazole,HCl (CAS 83763-11-5)
- N-(4-(tert-butyl)cyclohexyl)-2-chloroacetamide (CAS 500887-21-8)
- 3-Chloro-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (CAS 1211518-18-1)
- 1-methyl-4-(pyridin-3-yl)piperazine (CAS 223794-26-1)
- Rifapentine Impurity N1 (3-Formyl-Desacetyl Rifapentine) (CAS 16783-97-4)
- 4-Amino-2-chloro-N-(4-propoxyphenyl)benzamide (CAS 1456386-65-4)
- (Thr(PO3H2)231)-Tau Peptide (225-237) trifluoroacetate salt (CAS 1670270-09-3)
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