N-[4-(chloromethyl)-1,3-thiazol-2-yl]pyrimidin-2-amine CAS 97143-41-4
| CAS No. | 97143-41-4 |
| Molecular Formula | C8H7ClN4S |
| Molecular Weight | 226.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Structurally, N-[4-(chloromethyl)-1,3-thiazol-2-yl]pyrimidin-2-amine (C8H7ClN4S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 226.69 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
N-[4-(chloromethyl)-1,3-thiazol-2-yl]pyrimidin-2-amine (CAS 97143-41-4), molecular formula C8H7ClN4S and molecular weight 226.69 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-[4-(chloromethyl)-1,3-thiazol-2-yl]pyrimidin-2-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7ClN4S |
| Molecular Weight | 226.69 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 5-(6-Chloropyridin-3-yl)-4-methyl-4H-1,2,4-triazole-3-thiol (CAS 306936-79-8)
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- 4-Amino-5-(4-chloro-phenyl)-4H-[1,2,4]triazole-3-thiol (CAS 68468-95-1)
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- 2-(Dichloromethyl)-6-methylpyridine (CAS 56533-57-4)
- 1-fluoro-2-isothiocyanato-4-(trifluoromethyl)benzene (CAS 302912-40-9)
- Alectinib Impurity 7 (CAS 1256585-04-2)
- 2-(6-Chlorobenzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1154741-00-0)
- YM-53601 (CAS 182959-33-7)
- Vildagliptin Impurity 77 (CAS 5817-26-5)
- 4-Methoxy-2-methylbenzofuran (CAS 3781-89-3)
- 2-Bromo-3-methoxythiophene (CAS 174756-14-0)
- Semaglutide Impurity 125 xTFA Salt (CAS CATO-C4X-2226125)
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