Clofarabine Impurity 6 CAS 97614-43-2
| CAS No. | 97614-43-2 |
| Molecular Formula | C26H21FO7 |
| Molecular Weight | 464.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Clofarabine Impurity 6 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Clofarabine Impurity 6 (CAS 97614-43-2) is a certified pharmaceutical impurity reference standard with the molecular formula C26H21FO7 and a molecular weight of 464.44 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system, Clofarabine Impurity 6 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 464.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H21FO7 |
| Molecular Weight | 464.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
Related Clofarabine Standards
- Clofarabine Impurity N2 (CAS 704916-12-1)
- Clofarabine Impurity 10 (CAS CATO-C4X-159310)
- Clofarabine Impurity 9 (CAS CATO-C4X-15939)
- Clofarabine Impurity 5 (CAS 14215-97-5)
- Clofarabine Impurity 4 (CAS 70832-64-3)
- Clofarabine Impurity 16 (CAS CATO-C4X-159316)
- Clofarabine Impurity 8 (CAS 111615-20-4)
- Clofarabine (CAS 123318-82-1)
Recommended Standards
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- Cefixime Impurity 111 (CAS CATO-C4X-1139111)
- Edoxaban Impurity 7 (CAS 1072-98-6)
- 4-(1-Aminocyclopropyl)benzonitrile (CAS 1014645-75-0)
- Finerenone Impurity 12 (CAS 2084136-51-4)
- 2-Cyclopropoxy-4-(dimethylamino)benzamide (CAS 1243476-19-8)
- (R)-(3,3-Dimethylazetidin-2-yl)methanol (CAS 1315049-19-4)
- 1-Benzoylanthracene-9,10-dione (CAS 61726-79-2)
- Amiflamine hydrogentartrate (CAS 84257-38-5)
- Atrial Natriuretic Polypeptide (4-28), human (CAS 95896-08-5)
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