Lenalidomide Impurity 16 CAS 98475-07-1
| CAS No. | 98475-07-1 |
| Molecular Formula | C9H8BrNO4 |
| Molecular Weight | 274.07 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Lenalidomide Impurity 16 (CAS 98475-07-1, C9H8BrNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lenalidomide Impurity 16 (C9H8BrNO4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C9H8BrNO4 |
| Molecular Weight | 274.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Lenalidomide Standards
- Lenalidomide Impurity 16 (CAS 133446-99-8)
- Lenalidomide Impurity 57 (CAS 90725-68-1)
- Lenalidomide Impurity 58 (CAS 88071-90-3)
- Lenalidomide Impurity 59 (CAS 88089-94-5)
- Lenalidomide Impurity 61 (CAS 132874-06-7)
- Lenalidomide Impurity 34 (CAS CATO-C4X-190334)
- Lenalidomide Impurity 17 (CAS 2197421-58-0)
- Lenalidomide Impurity 19 (CAS CATO-C4X-190319)
Recommended Standards
- α-D-Ribose-5-phosphate (CAS 34980-65-9（free base）)
- Methyl 6-Bromo-2-methyl-3-nitrobenzoate (CAS 731810-03-0)
- Methyl 5-bromo-6-formyl-2-methoxynicotinate (CAS 2750929-11-2)
- Methyl 5-Bromo-2-methyl-3-nitrobenzoate (CAS 220514-28-3)
- Prilocaine Impurity 56 (CAS CATO-C4X-193456)
- Brexpiprazole Impurity 73 (CAS 2138169-93-2)
- Perampanel Impurity 24 (CAS CATO-C4X-243024)
- Ac-Ser4-Cetrorelix X TFA Salt (CAS CATO-C4X-201414)
- 2-[2-(2-Methoxyethoxy)ethoxy]acetaldehyde (CAS 132997-94-5)
- trans-2-Benzyloxycyclobutanamine (CAS 1354421-97-8)
- 1-Methylcyclobutanecarboxylic Acid (CAS 32936-76-8)
- 5-(N,N-Dimethylsulfamoyl)-1-methyl-1H-indole-3-carboxylic acid (CAS 120729-92-2)
- Formaldehyde Hydrazone (CAS 6629-91-0)
- Semaglutide Impurity 138 (CAS CATO-C4X-2226138)
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