4-chloro-7-hydroxy-1,3-dihydro-2-benzofuran-1-one CAS 98557-01-8
| CAS No. | 98557-01-8 |
| Molecular Formula | C8H5ClO3 |
| Molecular Weight | 184.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-chloro-7-hydroxy-1,3-dihydro-2-benzofuran-1-one.
4-chloro-7-hydroxy-1,3-dihydro-2-benzofuran-1-one (CAS 98557-01-8), molecular formula C8H5ClO3 and molecular weight 184.58 g/mol, is a CATO reference standard with documented purity and traceability.
4-chloro-7-hydroxy-1,3-dihydro-2-benzofuran-1-one (C8H5ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-chloro-7-hydroxy-1,3-dihydro-2-benzofuran-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5ClO3 |
| Molecular Weight | 184.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
Related chloro Standards
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- (6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methanol (CAS 1175301-94-6)
- 4-Chloro-3,7-dihydro-1H-pyrrolo[2,3-b]pyridine-2,6-dione (CAS 1190313-44-0)
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Recommended Standards
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- 5-(chloromethyl)-3-(2-furyl)-1,2,4-oxadiazole (CAS 501653-22-1)
- 5-Iodo-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine (CAS 1196662-03-9)
- 3-((2-Chlorophenoxy)methyl)-4-methoxybenzohydrazide (CAS 832740-06-4)
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- 3-Phenyl-N-(thiazol-2-yl)acrylamide (CAS 300829-00-9)
- 3-(Chloromethyl)-6-methylpyridazine (CAS 1056644-40-6)
- 1-((9H-Fluoren-9-yl)methyl) 4-(tert-butyl) 2,3-dihydropyrazine-1,4-dicarboxylate (CAS 1228675-22-6)
- n-((1h-Imidazol-2-yl)methyl)hexan-1-amine (CAS 1223431-60-4)
- 1-(2,6-Dichlorobenzyl)-3-(2,6-dimethylmorpholine-4-carbonyl)pyridin-2(1H)-one (CAS 478048-20-3)
- n-(3-(Aminomethyl)phenyl)-N-methylmethanesulfonamide (CAS 869371-36-8)
- D-γ-Glu20-Side-Tirzepatide (CAS CATO-CPTD788929)
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