Tetracaine Impurity 13 CAS 99-77-4
| CAS No. | 99-77-4 |
| Molecular Formula | C9H9NO4 |
| Molecular Weight | 195.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Tetracaine Impurity 13 (CAS 99-77-4, C9H9NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tetracaine Impurity 13 (C9H9NO4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C9H9NO4 |
| Molecular Weight | 195.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Tetracaine Standards
- Tetracaine Impurity 16 (CAS CATO-C4X-192316)
- Tetracaine EP Impurity B (CAS 4740-24-3)
- Tetracaine Impurity N3 (CAS 94-25-7)
- Tetracaine EP Impurity B-d9 (CAS 1309935-92-9)
- Tetracaine EP Impurity C (CAS 71839-12-8)
- Tetracaine Impurity 22 (CAS 794457-79-7)
- Tetracaine Impurity 7 (CAS 10012-47-2)
- Tetracaine Related Compound 1 (CAS 131719-63-6)
Recommended Standards
- Dopamine Impurity 2 (CAS 39816-35-8)
- Glucosamine Hydrochloride Impurity F (CAS 3646-68-2)
- Dopamine Impurity 11 (CAS 22568-51-0)
- Labetalol Impurity 78 (CAS CATO-C4X-246678)
- Palbociclib Impurity 28 (CAS 571188-59-5)
- Conjugated Estrogens EP Impurity A (CAS 56050-04-5)
- Trilaciclib Impurity 16 (CAS CATO-C4X-304416)
- 1-(6-Chloro-4-oxo-4H-thiochromen-3-yl)piperidine-4-carboxamide (CAS 895799-58-3)
- (Trimethoxysilyl)methyl acrylate (CAS 21134-38-3)
- 4-{2-[2,4,6-Trioxotetrahydro-5(2H)-pyrimidinylidene]hydrazino}benzoic acid (CAS 314757-93-2)
- ((2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)glycine (CAS 300567-51-5)
- 4'-[1,3]Dioxolan-2-yl-biphenyl-2-ylamine (CAS 400749-83-9)
- N-(4-Isopropylphenyl)-2-(2-oxo-3-(3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)pyridin-1(2H)-yl)butanamide (CAS 1396557-16-6)
- Semaglutide impurity 30 (CAS CATO-C4X-222630)
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