Torasemide Impurity 12 CAS 99300-68-2
| CAS No. | 99300-68-2 |
| Molecular Formula | C16H20N4O4S |
| Molecular Weight | 364.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Torasemide Impurity 12 (CAS 99300-68-2), a pharmacopoeial impurity reference standard (molecular formula C16H20N4O4S, MW 364.42 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Torasemide Impurity 12 (C16H20N4O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Torasemide Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H20N4O4S |
| Molecular Weight | 364.42 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Torasemide Standards
- Torasemide Impurity 28 (CAS 58154-83-9)
- Torasemide Impurity 44 (CAS CATO-C4X-183644)
- Torasemide EP Impurity D (CAS 160972-33-8)
- Torasemide impurity 41 (CAS CATO-C4X-183641)
- Torasemide Impurity 15 (CAS CATO-C4X-183615)
- Torasemide Impurity 24 (CAS CATO-C4X-183624)
- Torasemide Impurity 42 (CAS CATO-C4X-183642)
- Torasemide Impurity 43 (CAS CATO-C4X-183643)
Recommended Standards
- Promethazine Impurity 50 (CAS CATO-C4X-141850)
- Nafamostat Impurity 42 (CAS CATO-C4X-133242)
- Bumetanide Impurity 135 (CAS 30170-22-0)
- Penicillin V methyl ester (CAS 2315-05-1)
- Galantamine Impurity 6 (CAS 60755-80-8)
- Ketorolac EP Impurity I (CAS 113502-55-9)
- Ceftibuten Impurity 6 (CAS CATO-C4X-18906)
- 1-Methyl-2-imidazolemethanamine (CAS 124312-73-8)
- [3-(trifluoromethyl)phenyl]methanesulfonamide (CAS 919353-96-1)
- 3,3'-(4-Methyl-1,3-phenylene)bis(oxazolidin-2-one) (CAS 93427-59-9)
- 1-Oxa-4,8-diazaspiro[4.5]decan-3-one (CAS 746543-82-8)
- (2-Amino-5-chlorophenyl)methanol (CAS 37585-25-4)
- 6,8-Dichloro-2-hydroxyquinoline-4-carboxylic acid (CAS 50504-24-0)
- Semaglutide (CAS 910463-68-2（free base）)
Why CATO?
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