Nintedanib Impurity 46 CAS 99846-70-5
| CAS No. | 99846-70-5 |
| Molecular Formula | C9H10Cl2N2O |
| Molecular Weight | 233.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Nintedanib Impurity 46 (CAS 99846-70-5), a pharmacopoeial impurity reference standard (molecular formula C9H10Cl2N2O, MW 233.09 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Nintedanib Impurity 46 (C9H10Cl2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H10Cl2N2O |
| Molecular Weight | 233.09 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Nintedanib Standards
- Nintedanib Impurity 4 (CAS 676326-36-6)
- Nintedanib Impurity 27 (CAS 150784-50-2)
- Nintedanib Impurity 63 (CAS 2653-15-8)
- Nintedanib Impurity 7 (CAS 2653-16-9)
- Nintedanib Impurity 155 (CAS CATO-C4X-1814155)
- Nintedanib Impurity 113 (CAS CATO-C4X-1814113)
- Nintedanib Impurity 111 (CAS CATO-C4X-1814111)
- Nintedanib Impurity 91 (CAS CATO-C4X-181491)
Recommended Standards
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- Lusutrombopag Impurity 4 (CAS CATO-C4X-20844)
- 6-(2-Methylpropyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 80065-99-2)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com