Afatinib Impurity 17 CAS CATO-C4X-100617
| CAS No. | CATO-C4X-100617 |
| Molecular Formula | C20H18Cl2FN5O |
| Molecular Weight | 434.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Afatinib Impurity 17.
Afatinib Impurity 17 (CAS CATO-C4X-100617) is a certified pharmaceutical impurity reference standard with the molecular formula C20H18Cl2FN5O and a molecular weight of 434.29 g/mol.
Afatinib Impurity 17 (C20H18Cl2FN5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Afatinib Impurity 17 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H18Cl2FN5O |
| Molecular Weight | 434.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Afatinib Standards
- Afatinib Impurity 34 (CAS CATO-C4X-100634)
- Afatinib Impurity 7 (CAS 2223677-64-1)
- Afatinib Impurity 89 (CAS 2983348-69-0)
- Afatinib Impurity 79 (CAS CATO-C4X-100679)
- Afatinib Impurity 30 (CAS CATO-C4X-100630)
- Afatinib Impurity 32 (CAS 2170273-17-1)
- Afatinib Impurity 18 (CAS CATO-C4X-100618)
- Afatinib Impurity 50 (CAS 2413212-25-4)
Recommended Standards
- N-(5-(4-Bromophenyl)-1,3,4-oxadiazol-2-yl)-2,2-diphenylacetamide (CAS 897735-69-2)
- Cyfluthrin (CAS 68359-37-5)
- N-(2,4-dichloro-5-(2-methoxyethoxy)phenyl)-N-(phenylsulfonyl)glycine (CAS 338967-51-4)
- beta-Cyfluthrin (CAS 1820573-27-0)
- Testosterone Enantate EP Impurity E (CAS 219296-36-3)
- Ampicillin Impurity 60 (CAS CATO-C4X-144360)
- Terbutaline impurity 98 (CAS CATO-C4X-118398)
- 6-BROMO-1,3-DIMETHYLINDOLIN-2-ONE (CAS 1555987-99-9)
- 2-Methyl-5-(4-trifluoromethyl-phenyl)-furan-3-carboxylic acid (CAS 672930-52-8)
- N1,N4-dicyclohexylterephthalamide (CAS 15088-29-6)
- 3,4,5-Triiodo-2,6-dimethylpyridine (CAS 98549-80-5)
- 3-chloro-2,4,6-trifluoro-benzenesulfonyl chloride (CAS 1566918-91-9)
- Ethyl N-Cbz-4-piperidineacetate (CAS 80221-26-7)
- Glucagon receptor antagonists-2 (CAS 202917-18-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com