Afatinib Impurity 79 CAS CATO-C4X-100679
| CAS No. | CATO-C4X-100679 |
| Molecular Formula | C21H23ClFN5O3 |
| Molecular Weight | 447.89 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Afatinib Impurity 79 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Afatinib Impurity 79 (CAS CATO-C4X-100679, C21H23ClFN5O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Afatinib Impurity 79 (C21H23ClFN5O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H23ClFN5O3 |
| Molecular Weight | 447.89 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Afatinib Standards
- Afatinib Impurity 18 (CAS CATO-C4X-100618)
- Afatinib Impurity 50 (CAS 2413212-25-4)
- Afatinib Impurity 34 (CAS CATO-C4X-100634)
- Afatinib Impurity 7 (CAS 2223677-64-1)
- Afatinib Impurity 89 (CAS 2983348-69-0)
- Afatinib Impurity 68 (CAS CATO-C4X-100668)
- Afatinib Impurity 14 (CAS 2121530-37-6)
- Afatinib Impurity 19 (CAS 2223677-58-3)
Recommended Standards
- Elvitegravir (CAS 697761-98-1)
- Gefitinib Impurity 15 (CAS 1608115-59-8)
- 5-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)-N-(pyridin-2-ylmethyl)thiophene-2-sulfonamide (CAS 321430-91-5)
- (E)-N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-2-(4-isopropylphenyl)ethene-1-sulfonamide (CAS 478246-24-1)
- Ivabradine Impurity 14 (CAS CATO-C4X-111914)
- Roflumilast Impurity 61 (CAS CATO-C4X-193561)
- Fluorouracil Impurity 31 (CAS 58629-87-1)
- (E)-3-(3-((4-bromo-3,5-dimethyl-1H-pyrazol-1-yl)methyl)-4-methoxyphenyl)acrylic acid (CAS 1020050-90-1)
- tert-Butyl N-[1-(Aminomethyl)-2-methylcyclohexyl]carbamate (CAS 1392491-66-5)
- 2-Chloro-4-(3,4-difluorophenyl)-1-butene (CAS 951892-60-7)
- 4-Chloro-2-phenyl-7-(trifluoromethyl)quinoline (CAS 1189105-81-4)
- Atomoxetine impurity 40 (CAS 1010818-92-4)
- Butyl[(thiophen-2-yl)methyl]amine (CAS 58924-53-1)
- Glu17-Semaglutide (CAS CATO-C4X-2226209)
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