Apremilast Impurity 113 CAS CATO-C4X-1009113
| CAS No. | CATO-C4X-1009113 |
| Molecular Formula | C12H18O4S |
| Molecular Weight | 258.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Apremilast Impurity 113.
As a process- or degradation-related impurity, Apremilast Impurity 113 (CAS CATO-C4X-1009113, C12H18O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Apremilast Impurity 113 (C12H18O4S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H18O4S |
| Molecular Weight | 258.33 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Sulfur Atoms | 1 |
Related Apremilast Standards
- Apremilast impurity 128 (CAS 2489621-73-8)
- Apremilast Impurity 21 (CAS CATO-C4X-100921)
- Apremilast Impurity 57 (CAS 1255909-25-1)
- Apremilast Impurity 31 (CAS 1831833-38-5)
- Apremilast Impurity 106 (CAS CATO-C4X-1009106)
- Apremilast Impurity 41 (CAS 1450657-31-4)
- Apremilast Impurity 81 (CAS CATO-C4X-100981)
- Apremilast Impurity 22 (CAS CATO-C4X-100922)
Recommended Standards
- 3-Hydroxy-2,2-dimethylpropyl 4-methylbenzenesulfonate (CAS 21651-04-7)
- 2-Hydroxyethyl 4-(tert-butyl)benzenesulfonate (CAS 1413393-94-8)
- Calcitonin Impurity 18 (CAS CATO-C4X-221818)
- Tert-butyl 6-fluoro-2,8-diazaspiro[4.5]Decane-8-carboxylate (CAS 2306263-68-1)
- Rosuvastatin Impurity 61 (CAS 124752-23-4)
- Fulvestrant EP Impurity B (CAS 98008-06-1)
- Mirogabalin Impurity 13 (CAS 1798817-68-1)
- (3-Oxo-1,3-dihydroisobenzofuran-1,1-diyl)bis(4,1-phenylene) diacetate (CAS 5449-84-3)
- tert-Butyl 8-bromo-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate (CAS 851045-04-0)
- 2-(1-Ethyl-2,4-dioxo-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)acetic acid (CAS 1708080-05-0)
- (R)-2-Amino-3-mesitylpropanoic acid (CAS 146277-48-7)
- 4-Cyano-3-(4-fluorophenyl)propiophenone (CAS 141892-93-5)
- 1-(Tert-butyl)-3-(difluoromethyl)-1H-pyrazol-5-ol (CAS 1564723-92-7)
- Dendroaspis Natriuretic Peptide (CAS 255721-52-9)
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